Простая высокоинформативная метрика для оценки качества изображений в биомедицинских системах

The diabetic nephropathy is associated with oxidative stress and increases in pigment epithelium-derived factor (PEDF) level in the patient’s blood. For the first time, authors investigated the effect of methylethylpiridinol addition to the therapy on oxidative status and pigment epithelium-derived factor concentrations, and examined the relationship between these indicators and clinical markers of pathology development. Study design: open label randomized controlled trial study. Authors assessed the effect of methylethylpiridinol addition to the therapy vs basic treatment on antioxidant and NADPH-generating enzymes activity, glutathione’s concentration and free radical-induced oxidation’s intensity using a spectrophotometric method and iron-induced biochemiluminescence. The pigment epithelium-derived factor concentration in the serum was measured by enzyme-linked immunosorbent assay. Patients receiving combination therapy with methylethylpiridinol showed a more substantial increase in activity of glutathione peroxidase (Δ = 0.04 ± 0.11, p = 0.002), glutathione transferase (Δ = 0.12 ± 0.08, p < 0.001) and the concentration of reduced glutathione (Δ = 0.30 ± 0.17, p = 0.039). In addition, there was a significant decrease in PEDF level (Δ = -6.4 ± 5.4, p = 0.004). Correlation analysis showed a negative link between Δ postprandial glucose and Δ NADP-isocitrate dehydrogenase (-0.39, p = 0.033), Δ reduced glutathione and Δ postprandial glucose (-0.372, p = 0.043), Δ glutathione transferase and Δ PEDF (-0.37, p = 0.044). The methylethylpiridinol addition to the therapy had a more potent stimulating effect on the patients’ oxidative status in comparison with standard treatment, and reliably decreased pigment epithelium-derived factor level in patients’ serum. The observed differences seem to be associated with the antioxidant activity of methylethylpiridinol which contributing to the mitigation of oxidative stress reducing at diabetes mellitus.

The effect of methylethylpiridinol addition to the therapy on the level of pigment epithelium-derived factor and oxidative status in patients with diabetic nephropathy: randomized controlled open-label clinical study

Мультиспиральная компьютерная коронарография в диагностике коронарного атеросклероза

Коронарный атеросклероз у больных ревматоидным артритом: новые данные

Механизмы защитного действия Фэтила на проростки пшеницы при засолении

/pdf/markers-of-oxidative-stress-in-patients-with-coronary-heart-hfzjorq4ju.pdf

Markers of Oxidative Stress in Patients with Coronary Heart Disease

Aim. The aim of the research was to study the role of chaperone activity heat shock proteins (HSP) 70 in pathogenesis and diagnostic in patients with coronary atherosclerosis. Materials and methods. We examined 354 patients with coronary heart disease, who had coronary atherosclerosis of varying degrees, according to coronary angiography (was performed by the Judkins technique). The severity of coronary atherosclerosis was determined on the basis of the Gensini index. According to the Gensini index, patients were divided into 2 groups: GS0 - 152 patients without signs of coronary atherosclerosis, GS1 - 202 patients with coronary lesions. Chaperone activity was determined by thermodynamic method. Results. The study showed significant differences in the level of chaperone activity HSP70 in patients with different severity of coronary atherosclerosis. The correlation analysis revealed a significant negative relationship between chaperone activity HSP70 and the Gensini index. The cut-off value of chaperone activity of HSP70, by which can be judged on the presence or absence of coronary atherosclerosis, is establish. Conclusion. The revealed threshold of chaperone activity can be considered as a possible marker of the severity of coronary atherosclerosis.

https://cardiosomatics.orscience.ru/2221-7185/article/download/45947/pdf

Diagnostic value of chaperone activity of heat shock proteins 70 in coronary atherosclerosis

/pdf/relationship-between-indices-of-oxidative-stress-endothelial-sak4xmts6x.pdf

Relationship Between Indices of Oxidative Stress, Endothelial Dysfunction and Chaperone Activity and the Severity of Coronary Atherosclerosis

The purpose of our research was to analyze the association between the serum beta-NGF level and the severity of neurological deficit (ND) in children in the first year of life. Our results suggest a possible functional link between the low level of NGF and the development of severe ND. The obtained results allow us to consider the serum beta-NGF level as a useful marker of the ND severity in young children.(Int J Biomed. 2016; 6(4):276-278.)

http://ijbm.org/articles/IJBM_6(4)_OA5.pdf

Role of Nerve Growth Factor in Assessing the Severity of Clinical Manifestations and Outcomes of Perinatal CNS Lesions in Infants

http://ijbm.org/articles/IJBM_7(4)_OA2.pdf

Serum Level of Homocysteine and Perinatal CNS Lesions in Infants

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