Julia Kofler

TL;DR: In postmortem brain tissue from individuals with idiopathic PD (iPD), LRRK2 kinase activity is aberrantly increased in vulnerable nigrostriatal dopamine neurons, suggesting that L RRK2 Kinase inhibitors may be useful for treating patients with iPD and PD patients carrying LRRk2 mutations.

TL;DR: Cerebral neurofibrillary tangles burden, in addition to α-synuclein pathology and amyloid plaque pathology, are the strongest pathological predictors of a shorter interval between onset of motor and dementia symptoms and survival.

TL;DR: This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies.

TL;DR: The formation of pathologically relevant inclusions is driven by aberrant interactions between low-complexity domains of TDP-43 that are antagonized by RNA binding, and it is shown that aberrant phase transitions of cytoplasmic TTP are neurotoxic and that treatment with oligonucleotides composed of T DP-43 target sequences prevent inclusions and rescue neurotoxicity.