Julia Höbaus
Medical University of Vienna
10 Papers
Julia Höbaus is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Vitamin D and neurology & Calcitriol receptor. The author has an hindex of 10, co-authored 10 publications.
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Papers
Vitamin D and the epigenome
TL;DR: Regulation of the vitamin D system by epigenetic modifications and how vitamin D contributes to the maintenance of the epigenome is discussed, and its impact in health and disease is evaluated.
Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases in Carcinogenesis
TL;DR: The present review describes the role of the vitamin D hydroxylases in cancer pathogenesis and the cross-talk between the extra-renal autocrine/paracrine vitamin D system and calcium in cancer prevention.
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Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
Julia Höbaus,Doris M. Hummel,Ursula Thiem,Irfete S. Fetahu,Abhishek Aggarwal,Leonhard Müllauer,Gerwin Heller,Gerda Egger,Ildiko Mesteri,Sabina Baumgartner-Parzer,Enikö Kállay +10 more
TL;DR: High copy‐number gain is a key determinant of CYP24A1 overexpression in CRC, and other postulated causes including promoter hypomethylation and enhanced VDR and/or RXR expression do not appear to be involved.
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Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis
Doris M. Hummel,Ursula Thiem,Julia Höbaus,Ildiko Mesteri,Lukas Gober,Caroline Stremnitzer,João Graça,Barbara Obermayer-Pietsch,Enikö Kállay +8 more
TL;DR: High dietary vitamin D was able to prevent premalignant lesions caused by AOM/DSS and serum 25-D3 levels over 30 ng/ml are needed to prevent tumorigenesis.
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Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3
Irfete S. Fetahu,Julia Höbaus,Abhishek Aggarwal,Doris M. Hummel,Samawansha Tennakoon,Ildiko Mesteri,Sabina Baumgartner-Parzer,E. Kállay +7 more
TL;DR: The data show that hypermethylation of the CaSR promoter and H3K9 deacetylation, but not H 3K4me2 demethylation are important factors that cause silencing of the calcium‐sensing receptor in colorectal cancer.
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