Julia Flunkert
University of Würzburg
6 Papers
10 Citations
Julia Flunkert is an academic researcher from University of Würzburg. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 6, co-authored 6 publications.
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Papers
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
Steve Horvath,Junko Oshima,Junko Oshima,George M. Martin,Ake T. Lu,Austin Quach,Howard Cohen,Sarah Felton,Mieko Matsuyama,Donna Lowe,Sylwia Kabacik,James G. Wilson,Alexander P. Reiner,Anna Maierhofer,Julia Flunkert,Abraham Aviv,Lifang Hou,Andrea A. Baccarelli,Yun Li,James D. Stewart,Eric A. Whitsel,Luigi Ferrucci,Shigemi Matsuyama,Ken Raj +23 more
- 01 Jul 2018
TL;DR: A novel and highly robust DNAm age estimator for human fibroblasts, keratinocytes, buccal cells, endothelial cells, lymphoblastoid cells, skin, blood, and saliva samples that uncovered an epigenetic age acceleration with a magnitude below the sensitivity levels of other DNAm-based biomarkers.
Accelerated epigenetic aging in Werner syndrome.
Anna Maierhofer,Julia Flunkert,Junko Oshima,George M. Martin,Thomas Haaf,Steve Horvath +5 more
- 01 Apr 2017
TL;DR: Overall, this study shows that WS is associated with an increased epigenetic age of blood cells which is independent of changes in blood cell composition, and the extent to which this alteration is a cause or effect of WS disease phenotypes remains unknown.
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Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes
Anna Maierhofer,Julia Flunkert,Junko Oshima,Junko Oshima,George M. Martin,Martin Poot,Indrajit Nanda,Marcus Dittrich,Tobias Müller,Thomas Haaf +9 more
TL;DR: It is proposed that transcriptional misregulation of downstream genes by the absence of WRN protein contributes to the variable premature aging phenotypes of WS.
29
Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3.
Charline Jansch,Katharina Günther,Jonas Waider,Georg C. Ziegler,Andrea Forero,Sina Kollert,Evgeniy Svirin,Dirk Pühringer,Chee Keong Kwok,Reinhard Ullmann,Anna Maierhofer,Julia Flunkert,Thomas Haaf,Frank Edenhofer,Klaus-Peter Lesch,Klaus-Peter Lesch,Klaus-Peter Lesch +16 more
TL;DR: Fibroblasts were isolated from a skin biopsy of a clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3), which can be used to study the role of risk genes in the pathogenesis of ADHD, in a patient-specific manner.
12
Analysis of global DNA methylation changes in primary human fibroblasts in the early phase following X-ray irradiation.
Anna Maierhofer,Julia Flunkert,Marcus Dittrich,Tobias Müller,Detlev Schindler,Indrajit Nanda,Thomas Haaf +6 more
TL;DR: The authors' data suggest that global DNA methylation remains rather stable in irradiated normal body cells in the early phase of DNA damage response, and α-satelliteDNA methylation positively correlated with gestational age.