Julia E. Sim
Washington University in St. Louis
14 Papers
118 Citations
Julia E. Sim is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Oxidative stress & Biology. The author has an hindex of 14, co-authored 14 publications.
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Papers
Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?
TL;DR: It is proposed that intracellular oxidation/reduction reactions involving hydroperoxides and thiols may provide a mechanistic link between metabolism, signal transduction, and gene expression in these human tumor cells.
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Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.
Iman M. Ahmad,Nukhet Aykin-Burns,Julia E. Sim,Susan A. Walsh,Ryuji Higashikubo,Garry R. Buettner,Sujatha Venkataraman,Michael A. Mackey,Shawn W. Flanagan,Larry W. Oberley,Douglas R. Spitz,Douglas R. Spitz +11 more
TL;DR: The hypothesis that mitochondrial O2*- and H2O2 significantly contribute to glucose deprivation-induced cytotoxicity and metabolic oxidative stress in human cancer cells is strongly supported.
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A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media.
Lisa A. Ridnour,Julia E. Sim,Michael Hayward,David A. Wink,Sean M. Martin,Garry R. Buettner,Douglas R. Spitz +6 more
TL;DR: The utility of these assays was demonstrated in the standardization of nitric oxide-saturated cell culture media, and the release ofNitric oxide by the NONOate compound DEA/NO.
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Glial cell type-specific responses to menadione-induced oxidative stress.
Scott B. Hollensworth,Cheun-Chen Shen,Julia E. Sim,Douglas R. Spitz,Glenn L. Wilson,Susan P. LeDoux +5 more
TL;DR: The results show that the differential susceptibility of glial cell types to menadione-induced oxidative stress and apoptosis appears to correlate with increased oxidative mt DNA damage and support the hypothesis that mtDNA damage could participate in the initiation of apoptosis.
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Evaluation of Parameters of Oxidative Stress after In Vitro Exposure to FMCW- and CDMA-Modulated Radiofrequency Radiation Fields
Graham J. Hook,Douglas R. Spitz,Julia E. Sim,Ryuji Higashikubo,Jack Baty,Eduardo G. Moros,Joseph L. Roti Roti +6 more
TL;DR: FMCW- and CDMA-modulated RF radiation did not alter the level of intracellular oxidants, accumulation of GSSG or induction of antioxidant defenses in IFN/LPS-stimulated cells, and no change in toxicity was observed.
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