The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.

Modified nucleosides, nucleotides, and nucleic acids, and uses thereof

Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.

Engineered nucleic acids and methods of use thereof

The present invention relates to the composition of polynucleotides, primary transcripts, and mmRNA molecules, and methods for their preparation, manufacture, and therapeutic use.

Modified polynucleotides for the production of biologics and proteins associated with human disease

Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.

Delivery and formulation of engineered nucleic acids

The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides. More specifically, the disclosure provides compositions, methods, processes, kits and devices for the design, preparation, manufacture and/or formulation of modified mRNA (mmRNA) molecules from primary transcripts. Methods of using mmRNA for treating conditions or diseases are also disclosed.

Modified polynucleotides for the production of secreted proteins

Fv-1 gene-specific resistance to eco tropic murine retro viruses can be transferred to permissive cells with RNA prepared from restrictive cells. The active RNA has a sedimentation coefficient of 20–2

Characterization of Fv-1 Gene-Product-Mediated Resistance Transfer

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Characterization of Fv-1 Gene-Product-Mediated Resistance Transfer