Julia C. Meitz
Stellenbosch University
13 Papers
118 Citations
Julia C. Meitz is an academic researcher from Stellenbosch University. The author has contributed to research in topics: Prostate cancer & Gene. The author has an hindex of 13, co-authored 13 publications. Previous affiliations of Julia C. Meitz include University of Warwick & The Royal Marsden NHS Foundation Trust.
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Papers
Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene
Stephen M. Edwards,Zsofia Kote-Jarai,Julia C. Meitz,Rifat Hamoudi,Questa Hope,Peter Osin,Rachel Jackson,Christine Southgate,Rashmi Singh,Alison Falconer,David P. Dearnaley,Audrey Ardern-Jones,A Murkin,A Dowe,J. Kelly,Sue Williams,Richard A. Oram,Margaret Stevens,Dawn Teare,A.J. Bruce Ponder,Simon A. Gayther,Doug Easton,Rosalind A. Eeles +22 more
TL;DR: It is confirmed that BRCA2 is a high-risk prostate-cancer-susceptibility gene and have potential implications for the management of early-onset prostate cancer, in both patients and their relatives.
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A Combined Genomewide Linkage Scan of 1,233 Families for Prostate Cancer–Susceptibility Genes Conducted by the International Consortium for Prostate Cancer Genetics
Jianfeng Xu,Latchezar Dimitrov,Bao Li Chang,Tamara S. Adams,Aubrey R. Turner,Deborah A. Meyers,Rosalind A. Eeles,Douglas F. Easton,William D. Foulkes,Jacques Simard,Graham G. Giles,John L. Hopper,Lovise Mahle,Pål Møller,Tim Bishop,Christopher P. Evans,Steve Edwards,Julia C. Meitz,Sarah Bullock,Questa Hope,Chih Iin Hsieh,Jerry Halpern,Raymond N. Balise,Ingrid Oakley-Girvan,Alice S. Whittemore,Charles M. Ewing,Marta Gielzak,Sarah D. Isaacs,Patrick C. Walsh,Kathleen E. Wiley,William B. Isaacs,Stephen N. Thibodeau,Shannon K. McDonnell,Julie M. Cunningham,Katherine E. Zarfas,Scott J. Hebbring,Daniel J. Schaid,Danielle M. Friedrichsen,Kerry Deutsch,Suzanne Kolb,Michael D. Badzioch,Gail P. Jarvik,Marta Janer,Leroy Hood,Elaine A. Ostrander,Elaine A. Ostrander,Janet L. Stanford,Ethan M. Lange,Ethan M. Lange,Jennifer L. Beebe-Dimmer,Caroline E. Mohai,Kathleen A. Cooney,Tarja Ikonen,Agnes Baffoe-Bonnie,Henna Fredriksson,Mika P. Matikainen,Teuvo L.J. Tammela,Joan E. Bailey-Wilson,Johanna Schleutker,Christiane Maier,Kathleen Herkommer,Josef Hoegel,Walther Vogel,Thomas Paiss,Fredrik Wiklund,Monica Emanuelsson,Elisabeth Stenman,Björn Anders Jonsson,Henrik Grönberg,Nicola J. Camp,James M. Farnham,Lisa A. Cannon-Albright,Daniela Seminara +72 more
TL;DR: A conservative interpretation of these results would be that if major PC-susceptibility genes do exist, they are most likely located in the regions generating suggestive or significant linkage signals in this large study.
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Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis
S M Edwards,D G R Evans,Questa Hope,A. R. Norman,Yolanda Barbachano,Sarah Bullock,Z Kote-Jarai,Julia C. Meitz,Alison Falconer,Peter Osin,Cyril Fisher,Michelle Guy,Sameer Jhavar,Amanda L. Hall,Lynne T. O'Brien,Beatrice N. Gehr-Swain,R A Wilkinson,Matthew S. Forrest,David P. Dearnaley,Audrey Ardern-Jones,Elizabeth Page,Doug Easton,Rosalind A. Eeles +22 more
TL;DR: BRCA2 germline mutation is an independent prognostic factor for survival in PrCa and patients with such patients should not be managed with active surveillance as they have more aggressive disease.
HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease.
Julia C. Meitz,Stephen M. Edwards,Doug Easton,A Murkin,Audrey Ardern-Jones,R A Jackson,S Williams,David P. Dearnaley,Michael R. Stratton,Richard S. Houlston,Rosalind A. Eeles +10 more
TL;DR: Any association between the Thr541 variant in the HPC2/ELAC2 gene and prostate cancer is likely to be weak, according to genotyping patients and UK, population based control individuals.
Results of a genome-wide linkage analysis in prostate cancer families ascertained through the ACTANE consortium.
Steve Edwards,Julia C. Meitz,Ros Eles,Christopher H. Evans,Doug Easton,John L. Hopper,Graham G. Giles,William D. Foulkes,Steven A. Narod,Jacques Simard,Mike Badzioch,Lovise Mahle +11 more
TL;DR: Genetic linkage studies have identified several chromosomal regions that may contain prostate cancer susceptibility loci but none has been definitively implicated.
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