Julia Bos
Pasteur Institute
20 Papers
99 Citations
Julia Bos is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Methionine sulfoxide reductase & Population. The author has an hindex of 9, co-authored 15 publications. Previous affiliations of Julia Bos include Princeton University & Centre national de la recherche scientifique.
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Papers
Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response.
John P. Pribis,Libertad García-Villada,Yin Zhai,Ohad Lewin-Epstein,Anthony Z. Wang,Jingjing Liu,Jun Xia,Qian Mei,Devon M. Fitzgerald,Julia Bos,Robert H. Austin,Christophe Herman,David Bates,Lilach Hadany,P. J. Hastings,Susan M. Rosenberg +15 more
TL;DR: The report that the fluoroquinolone antibiotic ciprofloxacin (cipro) induces mutations by triggering transient differentiation of a mutant-generating cell subpopulation, using reactive oxygen species (ROS) supports a model in which within-cell chromosome cooperation together with development of a "gambler" cell sub population promote resistance evolution without risking most cells.
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Methionine sulfoxide reduction and assimilation in Escherichia coli: new role for the biotin sulfoxide reductase BisC.
TL;DR: This work provides the first example of an enzyme that reduces free MetSO while having no activity on peptide-bound MetSO residues, and shows that BisC has an essential role in assimilation of oxidized methionines.
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Real-time tracking of bacterial membrane vesicles reveals enhanced membrane traffic upon antibiotic exposure.
TL;DR: In this article, the authors provide a quantitative analysis of the motion of individual membrane vesicles in living microbes using fluorescence microscopy, and they show that while vesicle free diffusion in the intercellular space is rare, Vesicles mostly disperse along the bacterial surfaces.
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Bacterial Route Finding and Collective Escape in Mazes and Fractals
Trung Phan,Ryan J. Morris,Matthew Black,Tuan K. Do,Ke-Chih Lin,Krisztina Nagy,James C. Sturm,Julia Bos,Robert H. Austin +8 more
TL;DR: Experiments show that E. coli bacteria employ a number of strategies to explore complex environments, navigating mazes and fractals much more efficiently than would be expected for a random walk.
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Gamblers: an Antibiotic-induced Evolvable Cell Subpopulation Differentiated by Reactive-oxygen-induced General Stress Response
John P. Pribis,Libertad García-Villada,Yin Zhai,Ohad Lewin-Epstein,Anthony Z. Wang,Jingjing Liu,Jun Xia,Qian Mei,Devon M. Fitzgerald,Julia Bos,Robert H. Austin,Christophe Herman,David Bates,Lilach Hadany,P. J. Hastings,Susan M. Rosenberg +15 more
TL;DR: The fluoroquinolone antibiotic ciprofloxacin (cipro) induces mutations that cause drug resistance by triggering differentiation of a mutant-generating cell subpopulation, using reactive oxygen species (ROS) to signal the sigma-S (σS) general-stress response.
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