Julia Böck
University of Würzburg
7 Papers
38 Citations
Julia Böck is an academic researcher from University of Würzburg. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 6, co-authored 7 publications.
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Papers
Epigenetic dysregulation in the developing Down syndrome cortex
Nady El Hajj,Marcus Dittrich,Julia Böck,Theo F. J. Kraus,Indrajit Nanda,Tobias Müller,Larissa Seidmann,Tim Tralau,Danuta Galetzka,Eberhard Schneider,Thomas Haaf +10 more
TL;DR: Bisulfite pyrosequencing and targeted RNA sequencing showed that several genes of PCDHG subfamilies A and B are hypermethylated and transcriptionally downregulated in fetal DS cortex, which is expected to reduce dendrite arborization and growth in cortical neurons.
CpG sites with continuously increasing or decreasing methylation from early to late human fetal brain development.
Eberhard Schneider,Marcus Dittrich,Julia Böck,Indrajit Nanda,Tobias Müller,Larissa Seidmann,Tim Tralau,Danuta Galetzka,Nady El Hajj,Thomas Haaf +9 more
TL;DR: The results promote the idea that reduced methylation dynamics during fetal brain development may predispose to autism, and define a subset of dDMPs exhibiting constant methylation changes from early to late pregnancy.
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Allele-specific methylation of imprinted genes in fetal cord blood is influenced by cis-acting genetic variants and parental factors.
Ramya Potabattula,Marcus Dittrich,Julia Böck,Larissa Haertle,Tobias Müller,Thomas von Hahn,Martin Schorsch,Nady El Hajj,Thomas Haaf +8 more
TL;DR: The study supports the idea that parental factors can have an impact, although of small effect size, on the epigenome of the next generation, providing an additional layer of complexity to phenotypic diversity.
21
Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation‐negative early‐onset and high‐risk breast cancer patients
Julia Böck,Silke Appenzeller,Larissa Haertle,Tamara Schneider,Andrea Gehrig,J. Schröder,Simone Rost,Beat Wolf,Claus R. Bartram,Christian Sutter,Thomas Haaf +10 more
TL;DR: It is proposed that epigenetic abnormalities in normal body cells are indicative of disturbed mechanisms for maintaining low methylation and appropriate expression levels and may be associated with an increased BC risk.
Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals.
Larissa Haertle,Anna Maierhofer,Julia Böck,Harald Lehnen,Yvonne Böttcher,Matthias Blüher,Martin Schorsch,Ramya Potabattula,Nady El Hajj,Silke Appenzeller,Thomas Haaf +10 more
TL;DR: It is proposed that during development and differentiation maintenance of differential methylation at most imprinting control regions may become to some extent redundant and the accumulation of stochastic and environmentally-induced methylation errors on the non-imprinted allele may increase epigenetic diversity between cells and individuals.