Judith Schütte
University of Cambridge
28 Papers
49 Citations
Judith Schütte is an academic researcher from University of Cambridge. The author has contributed to research in topics: Haematopoiesis & Myeloid leukemia. The author has an hindex of 16, co-authored 27 publications. Previous affiliations of Judith Schütte include University of Münster & University of Duisburg-Essen.
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Papers
Combinatorial transcriptional control in blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators
Nicola K. Wilson,Samuel D. Foster,Xiaonan Wang,Kathy Knezevic,Judith Schütte,Polynikis Kaimakis,Paulina M. Chilarska,Sarah Kinston,Willem H. Ouwehand,Elaine Dzierzak,John E. Pimanda,Marella F. T. R. de Bruijn,Berthold Göttgens +12 more
TL;DR: The power of genome-wide analysis of complex binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells is reported, providing the most comprehensive TF data set for any adult stem/ Progenitor cell type to date.
754
Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner
Yahya Saleh Al-Matary,Lacramioara Botezatu,Bertram Opalka,Judith Hönes,Robert F. Lams,Aniththa Thivakaran,Judith Schütte,Renata Köster,Klaus Lennartz,Thomas Schroeder,Rainer Haas,Ulrich Dührsen,Cyrus Khandanpour +12 more
TL;DR: It is reported that acute myeloid leukemia leads to the invasion of acute myELoid leukemia-associated macrophages into the bone marrow and spleen of leukemic patients and mice, and the transcriptional repressor Growth factor independence 1 is crucial in the process of macrophage polarization.
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Growth Factor Independence 1 Antagonizes a p53-Induced DNA Damage Response Pathway in Lymphoblastic Leukemia
Cyrus Khandanpour,James D. Phelan,Lothar Vassen,Judith Schütte,Riyan Chen,Shane R. Horman,Marie-Claude Gaudreau,Joseph Krongold,Jinfang Zhu,William E. Paul,Ulrich Dührsen,Bertie Gottgens,H. Leighton Grimes,Tarik Möröy,Tarik Möröy +14 more
TL;DR: Gfi1 restricts p53 activity and expression of proapoptotic p53 targets such as Bax, Noxa, and Puma and limits the expansion of primary human T-ALL xenografts in mice, suggesting that targeting Gfi1 could improve the prognosis of patients with T-all or other lymphoid leukemias.
78
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Jessica Barth,Jessica Barth,Khalil Abou-El-Ardat,Khalil Abou-El-Ardat,Denis Dalic,Nina Kurrle,Anna-Maria Maier,Sebastian Mohr,Judith Schütte,Lothar Vassen,Gabriele Greve,Gabriele Greve,Johannes Schulz-Fincke,Johannes Schulz-Fincke,Martin Schmitt,Milica Tosic,Eric Metzger,Gesine Bug,Gesine Bug,Cyrus Khandanpour,Sebastian Wagner,Sebastian Wagner,Michael Lübbert,Michael Lübbert,Manfred Jung,Manfred Jung,Hubert Serve,Hubert Serve,Roland Schüle,Tobias Berg,Tobias Berg +30 more
TL;DR: It is believed that targeting both enzymatic and scaffolding functions of LSD1 is required to efficiently treat AML, and the identified biomarkers may be relevant for the treatment of AML patients with LSD1 inhibitors.
60
Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells
Felicia S L Ng,Judith Schütte,David Ruau,Evangelia Diamanti,Rebecca Hannah,Sarah Kinston,Berthold Göttgens +6 more
TL;DR: Evidence is provided for widespread sequence-specific TF pair interaction with DNA that conforms to the ‘enhanceosome’ model, and associations between specific haematopoietic cell-types and motif-pairs are identified.
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