Jude Chenge
St. Jude Children's Research Hospital
5 Papers
19 Citations
Jude Chenge is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Chemistry & Mycobacterium tuberculosis. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Jude Chenge include University of Manchester.
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Papers
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
William C. Wright,Jude Chenge,Jingheng Wang,Hazel M. Girvan,Lei Yang,Sergio C. Chai,Andrew D. Huber,Jing Wu,Peter Oladimeji,Andrew W. Munro,Taosheng Chen +10 more
TL;DR: The results provide a structural basis for selective CYP3A5 inhibition, along with mechanistic insights, and highlight clobetasol as an important chemical tool for target validation.
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Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
Jude Chenge,Le Van Duyet,Shalini Swami,Kirsty J. McLean,Madeline E. Kavanagh,Anthony G. Coyne,Stephen E. J. Rigby,Myles R. Cheesman,Hazel M. Girvan,Colin Levy,Bernd Rupp,Jens Peter von Kries,Chris Abell,David Leys,Andrew W. Munro +14 more
TL;DR: The relatively polar active site of CYP126A1 distinguishes it from its most closely related sterol-binding P450s in M. tuberculosis, suggesting that further investigations will reveal its diverse substrate selectivity.
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Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis
Jude Chenge,Madeline E. Kavanagh,Max D. Driscoll,Kirsty J. McLean,Douglas B. Young,Teresa Cortes,Dijana Matak-Vinkovic,Colin Levy,Stephen E. J. Rigby,David Leys,Chris Abell,Andrew W. Munro +11 more
TL;DR: These data provide the first evidence that Mtb produces two different forms of CYP144A1 from alternative transcripts, with CYP 144A1-TRV generated from a leaderless transcript lacking a 5′-untranslated region and Shine-Dalgarno ribosome binding site.
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5
Jingheng Wang,Cameron D. Buchman,Jayaraman Seetharaman,Darcie J. Miller,Andrew D. Huber,Jing Wu,Sergio C. Chai,Efren Garcia-Maldonado,William C. Wright,Jude Chenge,Taosheng Chen +10 more
TL;DR: In this article, the crystal structure of CYP3A5 in complex with a previously reported selective inhibitor, clobetasol propionate (CBZ), has been reported.
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Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.
Madeline E. Kavanagh,Jude Chenge,Azedine Zoufir,Kirsty J. McLean,Anthony G. Coyne,Andreas Bender,Andrew W. Munro,Chris Abell +7 more
TL;DR: Fragment screening is an efficient approach for characterization of the ligand binding profile of an enzyme and has been applied here to study the family of cytochrome P450 enzymes expressed by Mycobacterium tuberculosis.
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