/pdf/the-advent-of-electrophilic-hydroxylamine-derived-reagents-21epx8xk.pdf

The advent of electrophilic hydroxylamine-derived reagents for the direct preparation of unprotected amines

Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO2 at Ambient Pressure

Synthesis of N-CF3 Amidines/Imidates/Thioimidates via N-CF3 Nitrilium Ions.

Abstract The departure into unknown chemical space is essential for the discovery of new properties and function. We herein report the first synthetic access to N‐trifluoromethylated formamides. The method involves the reduction of bench‐stable NCF3 carbamoyl fluorides and is characterized by operational simplicity and mildness, tolerating a broad range of functional groups as well as stereocenters. The newly made N−CF3 formamide motif proved to be highly robust and compatible with diverse chemical transformations, underscoring its potential as building block in complex functional molecules.

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202213829

Access to N−CF3 Formamides by Reduction of N−CF3 Carbamoyl Fluorides

Synthesis of N -CF 3 compounds through fluorination or trifluoromethylation of N -containing compounds has been extensively investigated. However, general access to N -CF 3 compounds simply from N -CF 3 secondary amines is hampered by the challenging preparation and instability of these amines, as well as a much lower reactivity due to the strong electron-withdrawing nature and steric bulk of the trifluoromethyl moiety. Herein, we report a general and highly efficient synthesis of N -CF 3 secondary amines with excellent isolated yields via the addition of the in situ generated difluoromethyl imine (R-N=CF 2 ) intermediates with hydrogen fluoride, which is mildly produced by triethylsilane and silver fluoride. N -CF 3 sulfonamides, highly desirable but scarce at present, are easily accessible from these valuable building blocks through an unprecedented route. This study will bring new vitality to the synthesis of N -CF 3  compounds.

General Access to N-CF3 Secondary Amines and Their Transformation to N-CF3 Sulfonamides.

N-CF3 compounds constitute valuable targets in medicinal chemistry. Extensive studies have been reported for the preparation of N-CF3 compounds through fluorination and trifluoromethylation of N-containing compounds. The development of new synthetic methods from abundant and easily available substrates is highly desirable but still challenging. Herein, we report the design and synthesis of novel N-Cbz- and N-Boc-N-trifluoromethyl hydroxylamine reagents by silver-mediated oxidative trifluoromethylation. These reagents have been successfully applied to the direct incorporation of a NCF3 moiety into the commonly used unsaturated substrates under photoredox catalysis. This protocol enables the efficient and regioselective C-H trifluoromethylamination of various (hetero)arenes, including complex bioactive molecules. Furthermore, a variety of alkenes, dienes, and isonitriles undergo tandem trifluoromethylamination/functionalization delivering structurally diverse N-trifluoromethyl aliphatic and heteroaromatic amines. Notably, previously unknown cyclic N-CF3 compounds including N-CF3 oxazolidinones and oxazolones were conveniently prepared with N-Boc-N-trifluoromethyl hydroxylamine reagents. Furthermore, diversification of the resulting α-trifluoromethylamino ketones afforded the largely underexplored N-alkenyl- and N-alkynyl-N-CF3 compounds.

General Synthesis of N-Trifluoromethyl Compounds with N-Trifluoromethyl Hydroxylamine Reagents.

The role of mobile cameras increased dramatically over the past few years, leading to more and more research in automatic image quality enhancement and RAW photo processing. In this Mobile AI challenge, the target was to develop an efficient end-to-end AI-based image signal processing (ISP) pipeline replacing the standard mobile ISPs that can run on modern smartphone GPUs using TensorFlow Lite. The participants were provided with a large-scale Fujifilm UltraISP dataset consisting of thousands of paired photos captured with a normal mobile camera sensor and a professional 102MP medium-format FujiFilm GFX100 camera. The runtime of the resulting models was evaluated on the Snapdragon's 8 Gen 1 GPU that provides excellent acceleration results for the majority of common deep learning ops. The proposed solutions are compatible with all recent mobile GPUs, being able to process Full HD photos in less than 20-50 milliseconds while achieving high fidelity results. A detailed description of all models developed in this challenge is provided in this paper.

pdf/learned-smartphone-isp-on-mobile-gpus-with-deep-learning-bqvsbyxh.pdf

Learned Smartphone ISP on Mobile GPUs with Deep Learning, Mobile AI & AIM 2022 Challenge: Report

Photoredox catalyzed C-H trifluoroethylamination of heteroarenes.

During the study age in computer science, postgraduates with various specialties need good mathematical foundation to process their research. Current problem is classical course "Applied Mathematics" did not organically combine to research directions in computer science, which leads to widespread occurrence that students' mathematical knowledge can not be applied in their real work. This paper first analyzes research major specialties in college of computer science, Inner Mongolia University. Then, this paper analyzes and researches on mathematical knowledge and methods of postgraduate students in these specialties. Therefore, a teaching reform of postgraduate course "Applied Mathematics" is presented directionally, which can improves fit degree of this course in study of computer science.

Teaching Research Driven by Specialty Directions for Postgraduate Course “Applied Mathematics” in Computer Science

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Papers

General Synthesis of N-Trifluoromethyl Compounds with N-Trifluoromethyl Hydroxylamine Reagents.

Learned Smartphone ISP on Mobile GPUs with Deep Learning, Mobile AI & AIM 2022 Challenge: Report

Photoredox catalyzed C-H trifluoroethylamination of heteroarenes.

Teaching Research Driven by Specialty Directions for Postgraduate Course “Applied Mathematics” in Computer Science