Background Acetaminophen is extensively used during pregnancy. But there is a lack of population-representative cohort studies evaluating its effects on a range of neuropsychological and behavioural endpoints. We aimed to assess whether prenatal exposure to acetaminophen is adversely associated with neurodevelopmental outcomes at 1 and 5 years of age. Methods This Spanish birth cohort study included 2644 mother-child pairs recruited during pregnancy. The proportion of liveborn participants evaluated at 1 and 5 years was 88.8% and 79.9%, respectively. Use of acetaminophen was evaluated prospectively in two structured interviews. Ever/never use and frequency of use (never, sporadic, persistent) were measured. Main neurodevelopment outcomes were assessed using Childhood Autism Spectrum Test (CAST), Conner's Kiddie Continuous Performance Test (K-CPT) and ADHD-DSM-IV form list. Regression models were adjusted for social determinants and co-morbidities. Results Over 40% of mothers reported using acetaminophen. Ever-exposed offspring had higher risks of presenting more hyperactivity/impulsivity symptoms [incidence rate ratio (IRR) = 1.41, 95% confidence interval (CI) 1.01-1.98), K-CPT commission errors (IRR = 1.10, 1.03-1.17), and lower detectability scores (coefficient β = -0.75, -0.13--0.02). CAST scores were increased in ever-exposed males (β = 0.63, 0.09-1.18). Increased effect sizes of risks by frequency of use were observed for hyperactivity/impulsivity symptoms (IRR = 2.01, 0.95-4.24) in all children, K-CPT commission errors (IRR = 1.32, 1.05-1.66) and detectability (β = -0.18, -0.36-0.00) in females, and CAST scores in males (β = 1.91, 0.44-3.38). Conclusions Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males and showed adverse effects on attention-related outcomes for both genders. These associations seem to be dependent on the frequency of exposure.

Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms

Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort

Objectives: Early detection leads to early intervention and improvement in prognosis of autism spectrum disorder(ASD). Argentina does not rely on standardized ASD screening tools used among its health professionals.Therefore, the reliability of the Argentinian version of the Modified Checklist for Autism in Toddlers (M-CHAT) was tested. Methods: A sample of children from the general population between 18 and 24 months (n5420) was used. Parents/caregivers completed the M-CHAT. The reliability, test-retest agreement between parents and Cronbach’s alpha were estimated. Results:Results indicate that the M-CHAT version for Argentina showed satisfactory reliability values of: a test– retest with a Kappa index equal to 1, an agreement between parents that showed Kappa values of 0.79, and an internal consistence – Cronbach’s alpha – of 0.76.Also, the adaptation of M-CHAT’s telephone follow-up interview (FUI) was included. Conclusions: It is a useful tool for its application in the Argentinian healthcare setting, in turn, prove beneficial for early diagnosis and intervention.

Modified checklist for autism in toddlers

Background: Although previous studies have reported negative associations between exposure to air pollution and cognition, studies of the effects of prenatal and postnatal exposures in early childh...

Association between Early Life Exposure to Air Pollution and Working Memory and Attention.

/pdf/posttraumatic-stress-disorder-anxiety-and-depression-3af1wwcwvz.pdf

Posttraumatic Stress Disorder, Anxiety and Depression Symptoms, and Psychosocial Treatment Needs in Colombians Internally Displaced by Armed Conflict: A Mixed-Method Evaluation

Manual Diagnostico y estadistico de los trastornos mentales

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Manual Diagnostico y estadistico de los trastornos mentales