Ju Shi
4 Papers
3 Citations
Ju Shi is an academic researcher. The author has contributed to research in topics: TREM2 & Microglia. The author has an hindex of 3, co-authored 4 publications.
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Papers
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Alicia A. Nugent,Karin Lin,Bettina Van Lengerich,Steve Lianoglou,Laralynne Przybyla,Sonnet S. Davis,Ceyda Llapashtica,Junhua Wang,Do Jin Kim,Dan Xia,Anthony Lucas,Sulochanadevi Baskaran,Patrick C.G. Haddick,Melina Lenser,Timothy K. Earr,Ju Shi,Jason C. Dugas,Benjamin J. Andreone,Todd P. Logan,Hilda Solanoy,Hang Chen,Ankita Srivastava,Suresh Poda,Pascal E. Sanchez,Ryan J. Watts,Thomas Sandmann,Giuseppe Astarita,Joseph W. Lewcock,Kathryn M. Monroe,Gilbert Di Paolo +29 more
TL;DR: Combining chronic demyelination paradigms and cell sorting with RNA sequencing and lipidomics, it is found that wild-type microglia acquire a disease-associated transcriptional state, while TREM2-deficientmicroglia remain largely homeostatic, leading to neuronal damage.
527
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
Kai Schlepckow,Kathryn M. Monroe,Gernot Kleinberger,Ludovico Cantuti-Castelvetri,Samira Parhizkar,Dan Xia,Michael Willem,Georg Werner,Nadine Pettkus,Bettina Brunner,Alice Sülzen,Brigitte Nuscher,Heike Hampel,Xianyuan Xiang,Regina Feederle,Sabina Tahirovic,Joshua I. Park,Rachel Prorok,Cathal Mahon,Chun-Chi Liang,Ju Shi,Do Jin Kim,Hanna Sabelström,Fen Huang,Gilbert Di Paolo,Mikael Simons,Joseph W. Lewcock,Christian Haass,Christian Haass +28 more
TL;DR: 4D9, which has a stalk region epitope close to the cleavage site, demonstrated dual mechanisms of action by stabilizing TREM2 on the cell surface and reducing its shedding, and concomitantly activating phospho‐SYK signaling, suggesting a protective function by driving microglia toward a disease‐associated state.
238
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Benjamin J. Andreone,Laralynne Przybyla,Ceyda Llapashtica,Anil Rana,Sonnet S. Davis,Bettina Van Lengerich,Karin Lin,Ju Shi,Yuan Mei,Giuseppe Astarita,Gilbert Di Paolo,Thomas Sandmann,Kathryn M. Monroe,Joseph W. Lewcock +13 more
TL;DR: In this article, the authors used genetically engineered human induced pluripotent stem cell-derived microglia-like cells to show that TREM2 signals through PLCγ2 to mediate cell survival, phagocytosis, processing of neuronal debris, and lipid metabolism.
198
Patent
Anti-trem2 antibodies and methods of use thereof
Hang Chen,Gilbert Di Paolo,Rui Hao,Joseph W. Lewcock,Alicia A. Nugent,Rishi Rakhit,Ju Shi,Rinkan Shukla,Bettina Van Lengerich,Yin Zhang,Nathan Moerke +10 more
- 14 Sep 2018
TL;DR: In this paper, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided, and in some embodiments, the antibody enhances TREM2 activity.
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