The invention relates to a group of nucleotide sequences for detecting the gene mutants of HBV, which comprise at least one of the nucleotide sequences from SEQ ID No.1 to SEQ ID No.15. The invention also provides the use of the sequences in detection of the gene mutants of HBV. When the nucleotide sequences are used, 10 common gene mutation loci of HBV can be detected. When used for detecting the gene mutants of the HBV, the nucleotide sequences have the advantages of high throughput, high sensitivity and high specificity, are low in detection cost and have a practical clinic promotion and application value.

Group of nucleotide sequences for detecting gene mutants of hepatitis B virus (HBV) and use thereof

The invention provides a polymorphism nucleic acid mass spectrometric detection method of a CYP3A5 gene rs776746 locus, and belongs to the technical field of single nucleotide polymorphism detection.The method comprises the following steps of 1, utilizing a CYP3A5 gene rs776746 locus primer for PCR amplification to obtain an amplification product with human genome DNA as a template; 2, utilizingshrimp alkaline phosphatase for dephosphorylating the amplification product obtained in step 1 to obtain dephosphorylated linear DNA fragments; 3, conducting single base group extension on the dephosphorylated linear DNA fragments obtained in step 2 to obtain an extension product; 4, adopting matrix-assisted laser analytical ionization time-of-flight mass spectrometry for detecting the extension product obtained in step 3 to obtain the polymorphism typing result of the CYP3A5 gene rs776746 locus. The detection method is accurate, efficient and quick.

Polymorphism nucleic acid mass spectrometric detection method of CYP3A5 gene rs776746 locus

Disclosed is a method for the detection of virus variations. Disclosed also is a method for the treatment of virus infection in a subject based on the detection of virus variations. Additionally, a kit is provided for the detection of virus variations.

Multiplex detection of hepatitis virus variations

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Multiplex detection of hepatitis virus variations