Joy Davis
University of Alberta
8 Papers
37 Citations
Joy Davis is an academic researcher from University of Alberta. The author has contributed to research in topics: Islet & Transplantation. The author has an hindex of 7, co-authored 8 publications.
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Papers
Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
Juliet Emamaullee,Joy Davis,Shaheed Merani,Christian Toso,John F. Elliott,Aducio Thiesen,A. M. James Shapiro +6 more
TL;DR: These studies suggest that Th17 cells are involved in the pathogenesis of autoimmune diabetes and further development of Th17-targeted therapeutic agents may be of benefit in this disease.
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Porcine Marginal Mass Islet Autografts Resist Metabolic Failure Over Time and Are Enhanced by Early Treatment with Liraglutide
Juliet Emamaullee,Shaheed Merani,Christian Toso,Tatsuya Kin,Faisal Al-Saif,Wayne Truong,Rena Pawlick,Joy Davis,Ryan Edgar,Jennifer Lock,Susan Bonner-Weir,Lotte Bjerre Knudsen,A. M. James Shapiro +12 more
TL;DR: Surprisingly, no evidence for deterioration of graft function was observed in any of the transplanted animals over more than 18 months of follow-up despite significant weight gain; in fact, an enhanced response to glucose developed over time even in control animals.
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The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice.
Michael McCall,Christian Toso,Christian Toso,Juliet Emamaullee,Rena Pawlick,Ryan Edgar,Joy Davis,Allison H. Maciver,Tatsuya Kin,Robert H. Arch,A. M. James Shapiro +10 more
TL;DR: The effectiveness of caspase inhibition with IDN-6556 on islet transplantation and in particular islet engraftment and survival is demonstrated and protective effects in vitro for islet viability are found.
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Caspase inhibitor therapy synergizes with costimulation blockade to promote indefinite islet allograft survival.
Juliet Emamaullee,Joy Davis,Rena Pawlick,Christian Toso,Shaheed Merani,Sui-Xiong Cai,Ben Tseng,A. M. James Shapiro +7 more
TL;DR: This study suggests that addition of caspase inhibitor therapy to costimulation blockade will improve clinical transplantation by minimizing immune stimulation and thus reduce the requirement for long-term immunosuppressive therapy.
Detecting rejection after mouse Islet transplantation utilizing islet protein-stimulated ELISPOT.
Christian Toso,Rena Pawlick,Stéphanie Lacotte,Ryan Edgar,Joy Davis,Michael McCall,Philippe Morel,Gilles Mentha,Thierry Berney,A. M. James Shapiro +9 more
TL;DR: Overall, allogeneic rejection was associated to a transient increase in the reactivity of splenocytes against islet proteins, which has the potential to improve islet graft monitoring in human and should be further explored.
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