Joseph E. Rotsinger
Vanderbilt University
7 Papers
9 Citations
Joseph E. Rotsinger is an academic researcher from Vanderbilt University. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Joseph E. Rotsinger include Wright State University.
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Papers
Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A/IL-23 axis
Alexander Gelbard,Nicolas George Katsantonis,Masanobu Mizuta,Dawn C. Newcomb,Joseph E. Rotsinger,Bernard Rousseau,James J. Daniero,Eric S. Edell,Dale C. Ekbom,Jan L. Kasperbauer,Alexander T. Hillel,Liying Yang,C. Gaelyn Garrett,James L. Netterville,Christopher T. Wootten,David O. Francis,Charles W. Stratton,Kevin Jenkins,Tracy L. McGregor,Jennifer A. Gaddy,Jennifer A. Gaddy,Timothy S. Blackwell,Timothy S. Blackwell,Wonder P. Drake +23 more
TL;DR: In this article, the authors presented the initial characterization of the molecular pathogenesis underlying the fibrosing phenotype of iSGS, and demonstrated significant activation of the canonical IL-23/IL-17A pathway in the tracheal mucosa of the patients, as well as identify γδ T cells as the primary cellular source of IL-17 A.
Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species
Alexander Gelbard,Nicolas George Katsantonis,Masanobu Mizuta,Dawn C. Newcomb,Joseph E. Rotsinger,Bernard Rousseau,James J. Daniero,Eric S. Edell,Dale C. Ekbom,Jan L. Kasperbauer,Alexander T. Hillel,Liying Yang,C. Gaelyn Garrett,James L. Netterville,Christopher T. Wootten,David O. Francis,Charles W. Stratton,Kevin Jenkins,Tracy L. McGregor,Jennifer A. Gaddy,Jennifer A. Gaddy,Timothy S. Blackwell,Timothy S. Blackwell,Wonder P. Drake +23 more
TL;DR: Idiopathic subglottic stenosis is an unexplained obstruction involving the lower laryngeal and upper tracheal airway and Epithelial microbiota dysbiosis is found in other chronic inflammatory mucosal diseases; however, the relationship between trachesal microbiota composition and iSGS is unknown.
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Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis
Charlene Hawkins,Guzel Shaginurova,D. Auriel Shelton,Jose D. Herazo-Maya,Kyra Oswald-Richter,Joseph E. Rotsinger,Anjuli Young,Lindsay J. Celada,Naftali Kaminski,Carla M. Sevin,Wonder P. Drake +10 more
TL;DR: Sarcoidosis CD4+ T cells exhibit loss of cellular function during progressive disease that follows the archetype of T cell exhaustion, which is defined by decreased cytokine production upon TCR activation, decreased proliferation, increased expression of inhibitory cell surface receptors, and increased susceptibility to apoptosis.
Sarcoidosis: Unknown Etiology and Genetic Predisposition Provides Therapeutic Challenges
TL;DR: Sarcoidosis is an idiopathic multisystem disorder characterized by noncaseating epithelioid granulomas predominately affecting lungs and lymph nodes, but with potential to affect any organ system as mentioned in this paper.
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