Joseph E. Pero
Merck & Co.
9 Papers
135 Citations
Joseph E. Pero is an academic researcher from Merck & Co.. The author has contributed to research in topics: Metabotropic glutamate receptor 2 & Metabotropic glutamate receptor. The author has an hindex of 5, co-authored 7 publications.
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Papers
Patent
Positive allosteric modulators of mglur2
Arrington Kenneth L,Vadim Dudkin,Mark E. Layton,Joseph E. Pero,Alexander J. Reif +4 more
- 28 Feb 2011
TL;DR: In this article, a 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives are used as positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.
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Benzoxazolinone aryl sulfonamides as potent, selective Na v 1.7 inhibitors with in vivo efficacy in a preclinical pain model
Joseph E. Pero,Michael A. Rossi,Hannah D. G. F. Lehman,Michael J. Kelly,James Mulhearn,Scott E. Wolkenberg,Matthew J. Cato,Michelle K. Clements,Christopher Daley,Tracey Filzen,Eleftheria N. Finger,Yun Gregan,Darrell A. Henze,Aneta Jovanovska,Rebecca M. Klein,Richard L. Kraus,Yuxing Li,Annie Liang,John Majercak,Jacqueline Panigel,Mark O. Urban,Jixin Wang,Ying-Hong Wang,Andrea K. Houghton,Mark E. Layton +24 more
TL;DR: Novel, peripherally-restricted benzoxazolinone aryl sulfonamides are reported as potentNav1.7 inhibitors with excellent selectivity against the Nav1.5 isoform, which is expressed in the heart muscle.
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Patent
Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
Mark E. Layton,Joseph E. Pero,Hannah D. Fiji,Michael J. Kelly,Pablo De Leon,Michael A. Rossi,Kevin F. Gilbert,Anthony J. Roecker,Zhijian Zhao,Swati P. Mercer,Scott E. Wolkenberg,James Mulhearn,Lianyun Zhao,Dansu Li +13 more
- 26 Oct 2012
TL;DR: In this paper, compounds of Formula (A) or a salt thereof, wherein "Het", Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons.
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Patent
Imidazopyridin-2-one derivatives
Hannah D. Fiji,Michael J. Kelly,Kern Jeffrey,Mark E. Layton,Joseph E. Pero,Alexander J. Reif,Michael A. Rossi +6 more
- 14 Jun 2012
TL;DR: In this paper, the use of imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which glutamate receptors are involved is discussed.
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Patent
N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels
Joseph E. Pero,Hannah D. G. F. Lehman,Mark E. Layton,Michael A. Rossi,Michael J. Kelly +4 more
- 23 Oct 2013
TL;DR: In this paper, compounds of Formula AA and Formula AB have been shown to have properties for blocking Nav 1.7 ion channels found in peripherial and sympathetic neurons, and methods of treating neuropathic pain disorders using the same.
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