Joseph E. LeClerc
Food and Drug Administration
11 Papers
60 Citations
Joseph E. LeClerc is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Genome & Virulence. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Joseph E. LeClerc include Center for Food Safety and Applied Nutrition.
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Papers
Quality Sample Collection, Handling, and Preservation for an Effective Microbial Forensics Program
Bruce Budowle,Steven E. Schutzer,James P. Burans,Douglas J. Beecher,Thomas A. Cebula,Ranajit Chakraborty,William T. Cobb,Jacqueline Fletcher,Martha L. Hale,Robert B. Harris,Michael A. Heitkamp,Frederick Paul Keller,Cheryl R. Kuske,Joseph E. LeClerc,Babetta L. Marrone,Thomas S. McKenna,Stephen A. Morse,Luis L. Rodriguez,Nancy B. Valentine,Jagjit Yadev +19 more
TL;DR: Issues related to the practices of sample collection, handling, transportation, and storage are presented and recommendations for future directions for the field of microbial forensics and people participating in it are included.
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Genomic Analysis of Immune Response against Vibrio cholerae Hemolysin in Caenorhabditis elegans
Surasri N. Sahu,Jada Lewis,Isha R. Patel,Serdar Bozdag,Jeong H. Lee,Jeong H. Lee,Joseph E. LeClerc,Hediye Nese Cinar +7 more
TL;DR: VCC is a major virulence factor, which induces a wide variety of immune response- related genes during V. cholerae infection in C. elegans, and several putative VCC induced immune regulatory transcriptional factors and transcription factor binding motifs are identified.
Investigating the global genomic diversity of Escherichia coli using a multi-genome DNA microarray platform with novel gene prediction strategies
TL;DR: This study was able to define sets of genes that correspond to, and therefore define, the EHEC pathogen type, and described an analysis method that utilizes the power of the probe sets to determine accurately the presence/absence of each gene represented on this array.
Genome Signatures of Escherichia coli O157:H7 Isolates from the Bovine Host Reservoir
TL;DR: This study catalogued numerous novel lineage II-specific genome signatures, some of which appear to be associated intimately with the altered pathogenic potential and niche adaptation within the bovine rumen, which is valuable in the development of a robust typing system critical for forensic, diagnostic, and epidemiological studies of this emerging human pathogen.
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The Pathogen-annotated Tracking Resource Network (PATRN) system: A web-based resource to aid food safety, regulatory science, and investigations of foodborne pathogens and disease
Gopal R. Gopinath,K. Hari,R. Jain,Mark K. Mammel,Mahendra H. Kothary,Augusto A. Franco,Christopher J. Grim,K. G. Jarvis,Venugopal Sathyamoorthy,Lan Hu,Atin R. Datta,Isha R. Patel,Scott A. Jackson,Jayanthi Gangiredla,Michael L. Kotewicz,Joseph E. LeClerc,M. Wekell,B. A. McCardell,M. D. Solomotis,Ben D. Tall +19 more
TL;DR: PATRN is a web-based integrated platform containing tools for the management, analysis and visualization of data about foodborne pathogens, and three use-case scenarios are presented.
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