Joseph A. Jurcisek
Nationwide Children's Hospital
45 Papers
188 Citations
Joseph A. Jurcisek is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Biofilm & Haemophilus influenzae. The author has an hindex of 27, co-authored 41 publications. Previous affiliations of Joseph A. Jurcisek include Ohio State University & The Research Institute at Nationwide Children's Hospital.
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Papers
Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins
Steven D. Goodman,Kyle P. Obergfell,Joseph A. Jurcisek,Laura A. Novotny,Jennifer S. Downey,Eduardo A. Ayala,Natalia O. Tjokro,Birong Li,Sheryl S. Justice,Lauren O. Bakaletz +9 more
TL;DR: It is shown that the DNABII family of proteins was also critical for the integrity of the EPS matrix of biofilms that contain eDNA, and this methodology to debulk the biofilm of EPS was shown to work synergistically with otherwise ineffective traditional anti-microbial approaches in vitro.
218
The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.
Joseph A. Jurcisek,James E. Bookwalter,Beth Baker,Soledad Fernandez,Laura A. Novotny,Robert S. Munson,Lauren O. Bakaletz +6 more
TL;DR: The data demonstrate that NTHI express PilA in vivo, and that PilA plays an important role in the pathogenesis of an upper respiratory tract infection induced by NTHi, both in vitro and in vivo.
153
Role of Sialic Acid and Complex Carbohydrate Biosynthesis in Biofilm Formation by Nontypeable Haemophilus influenzae in the Chinchilla Middle Ear
Joseph A. Jurcisek,Laura L Greiner,Hiroshi Watanabe,Anthony Zaleski,Michael A. Apicella,Lauren O. Bakaletz +5 more
TL;DR: It is found that when modeled in a mammalian host, whereas biofilm formation was not essential for survivability of NTHI in vivo, lipooligosaccharide sialylation was indispensable.
148
Z-form extracellular DNA is a structural component of the bacterial biofilm matrix
John R. Buzzo,Aishwarya Devaraj,Erin S. Gloag,Joseph A. Jurcisek,Frank Robledo-Avila,Theresa Kesler,Kathryn Wilbanks,Lauren Mashburn-Warren,Sabarathnam Balu,Joseph Wickham,Laura A. Novotny,Paul Stoodley,Paul Stoodley,Lauren O. Bakaletz,Lauren O. Bakaletz,Steven D. Goodman,Steven D. Goodman +16 more
TL;DR: In this article, the role of Z-DNA in biofilm pathogenesis, innate immune response, and immune evasion was investigated and it was shown that the universal bacterial DNABII family of proteins stabilizes both bacterial and host eDNA in the Z-form in situ.
112
Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo
Laura A. Novotny,Laura A. Novotny,Joseph A. Jurcisek,Joseph A. Jurcisek,Steven D. Goodman,Steven D. Goodman,Lauren O. Bakaletz,Lauren O. Bakaletz +7 more
TL;DR: It is shown that a cocktail of monoclonal antibodies directed against specific epitopes of a DNABII protein is highly effective to disrupt diverse biofilms in vitro as well as resolve experimental infection in vivo, in both a chinchilla and murine model.
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