Joseph A. Fuselier
Tulane University
40 Papers
257 Citations
Joseph A. Fuselier is an academic researcher from Tulane University. The author has contributed to research in topics: Somatostatin & Camptothecin. The author has an hindex of 18, co-authored 38 publications. Previous affiliations of Joseph A. Fuselier include University Medical Center New Orleans & LSU Health Sciences Center New Orleans.
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Papers
Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design
TL;DR: A series of novel 1,4-diaryl-2-azetidinones prepared by stereospecific Staudinger reaction as conformationally restricted analogues of combretastatin A-4 were evaluated for cytotoxicity against a number of human tumor and normal cell lines.
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A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, αVβ3/αVβ5 and MMP-2/-9
TL;DR: The results support that this conjugate could possibly inhibit prostate cancer PC-3 cell invasion through a signaling pathway involving PI3K/Akt, αVβ3/αVβ5 and MMP-2/-9, and this SSA could be used as an efficient vector to deliver CPT or other cytotoxic agents to target sites for cancer therapy.
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Patent
Conjugates of therapeutic or cytotoxic agents and biologically active peptides
Joseph A. Fuselier,David H. Coy +1 more
- 03 Mar 2003
TL;DR: In this paper, the authors describe conjugates of therapeutic or cytotoxic agents and biologically active peptides and methods of use thereof, including methods of synthesis and use of peptides.
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Notch1-Mediated Tumor Suppression in Cervical Cancer with the Involvement of SST Signaling and Its Application in Enhanced SSTR-Targeted Therapeutics
Laura G. Franko-Tobin,L. Vienna Mackey,Wei Huang,Xiangwei Song,Baofeng Jin,Jing Luo,Lynsie Morris,Minqiu Liu,Joseph A. Fuselier,David H. Coy,Lizi Wu,Lichun Sun +11 more
TL;DR: These findings provide a promising clinical opportunity for enhanced cancer therapy using combinations of Notch1-activating agents and SSTR2-targeting agents and support a possible crosstalk between Notch signaling and SST signaling.
39
Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma IMR32 cells expressing somatostatin receptors
TL;DR: This study indicates that PNAs conjugated to SSA exhibited improved inhibition of gene expression possibly due to facilitated cellular uptake of the PN as in the PNA antisense strategy.
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