Joseph A. Frank
National Institutes of Health
323 Papers
5.6K Citations
Joseph A. Frank is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Magnetic resonance imaging & Medicine. The author has an hindex of 91, co-authored 320 publications. Previous affiliations of Joseph A. Frank include Georgetown University Medical Center & Uniformed Services University of the Health Sciences.
Chat about Author
Papers
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand.
Bibiana Bielekova,Bonnie Goodwin,Nancy Richert,Irene Cortese,Takayuki Kondo,Ghazaleh Afshar,Bruno Gran,Joan M. Eaton,Jack P. Antel,Joseph A. Frank,Henry F. McFarland,Roland Martin +11 more
TL;DR: Three patients developed exacerbations of multiple sclerosis, and in two this could be linked to altered peptide ligand treatment by immunological studies demonstrating the encephalitogenic potential of the myelin basic protein peptide in a subgroup of patients, which raise important considerations for the use of specific immunotherapies in general.
874
Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents.
Joseph A. Frank,Brad Miller,Ali S. Arbab,Holly A. Zywicke,E. Kay Jordan,Bobbi K. Lewis,L. Henry Bryant,Jeff W.M. Bulte +7 more
TL;DR: Magnetic labeling of mammalian cells with use of ferumoxides and TAs is possible and may enable cellular MR imaging and tracking in experimental and clinical settings.
701
Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance
TL;DR: Atrophy provides a sensitive measure of the neurodegenerative component of multiple sclerosis and should be measured in trials evaluating potential anti-inflammatory, remyelinating or neuroprotective therapies.
Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis
DH Miller,Paul S. Albert,Frederik Barkhof,Gordon S. Francis,Joseph A. Frank,Suzanne Hodgkinson,Fred D. Lublin,Donald W. Paty,Stephen C. Reingold,J. Simon +9 more
TL;DR: To provide international consensus guidelines for the use of MRI in MS clinical trials, a task force of the US National MS Society was convened and the recommendations of the task force are presented in this review.
493
Echo-planar time course MRI of cat brain oxygenation changes.
TL;DR: Change images demonstrate that blood oxygenation is increased during periods of recovery from respiratory challenge and changes in brain oxygenation can be monitored using gradient‐echo echo‐planar imaging.