Josep Quer
Carlos III Health Institute
141 Papers
464 Citations
Josep Quer is an academic researcher from Carlos III Health Institute. The author has contributed to research in topics: Viral quasispecies & Hepatitis C virus. The author has an hindex of 34, co-authored 110 publications. Previous affiliations of Josep Quer include Spanish National Research Council & University of Barcelona.
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Papers
Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution.
María Martell,J.I. Esteban,Josep Quer,Joan Genescà,A Weiner,Rafael Esteban,Jaime Guardia,Jordi Gómez +7 more
TL;DR: It is estimated that most circulating particles should contain defective genomes, which might have important implications in the physiopathology of HCV infection and underline the need for a population-based approach when one is analyzing HCV genomes.
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The changing epidemiology of hepatitis C virus infection in Europe.
TL;DR: This review summarizes recently published data on the epidemiology of HCV infection in Europe focusing on the factors currently shaping the epidemic and recommends new preventive strategies implemented to control the silent epidemic.
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The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer
Agustín F. Fernández,Cecilia Rosales,Pilar López-Nieva,Osvaldo Graña,Esteban Ballestar,Santiago Ropero,Jesús Espada,Sonia A. Melo,Amaia Lujambio,Mario F. Fraga,Irene Pino,Biola M. Javierre,Francisco J. Carmona,Francesco Acquadro,Renske D.M. Steenbergen,Peter J.F. Snijders,Chris J.L.M. Meijer,Pascal Pineau,Anne Dejean,Belen Lloveras,Gabriel Capellá,Josep Quer,Maria Buti,Juan Lgnacio Esteban,Helena Allende,Francisco Rodriguez-Frias,Xavier Castellsagué,Janos Minarovits,Jordi Ponce,Daniela Capello,Gianluca Gaidano,Juan C. Cigudosa,Gonzalo Gómez-López,David G. Pisano,Alfonso Valencia,Miguel A. Piris,Francesc Bosch,Ellen Cahir-McFarland,Elliott Kieff,Manel Esteller +39 more
TL;DR: The DNA methylomes presented provide evidence of the dynamic nature of the epigenome in contrast to the genome, and it is observed that the DNA methylome of these viruses evolves from an unmethylated to a highly methylated genome in association with the progression of the disease.
Extreme fitness differences in mammalian and insect hosts after continuous replication of vesicular stomatitis virus in sandfly cells.
Isabel S. Novella,D K Clarke,Josep Quer,E A Duarte,C. H. Lee,Scott C. Weaver,Santiago F. Elena,Andrés Moya,Esteban Domingo,John J. Holland +9 more
TL;DR: The results clearly illustrate the enormous capacity of RNA viruses to adapt to changing selective environments with extreme selective differences in the environmental conditions provided by insect and mammalian cells.
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Viral quasispecies complexity measures
Josep Gregori,Josep Gregori,Josep Gregori,Celia Perales,Francisco Rodriguez-Frias,Juan Ignacio Esteban,Josep Quer,Esteban Domingo +7 more
TL;DR: This work critically evaluates the information provided by several population diversity indices, and proposes the introduction of some new ones used in ecology, and makes a distinction between incidence, abundance and function measures of viral quasispecies composition.
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