Josef M. Penninger
University of British Columbia
749 Papers
5.2K Citations
Josef M. Penninger is an academic researcher from University of British Columbia. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 154, co-authored 700 publications. Previous affiliations of Josef M. Penninger include Austrian Academy of Sciences & Amgen.
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Papers
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection
Seiki Fujiwara,Midori Hoshizaki,Yu Ichida,Dennis Lex,Etsushi Kuroda,Ken Ishii,Shigeyuki Magi,Mariko Okada,Hiroyuki Takao,Masahiro Gandou,Hirotaka Imai,Ryujiro Hara,Herbert Herzog,Akihiko Yoshimura,Hitoshi Okamura,Josef M. Penninger,Josef M. Penninger,Arthur S. Slutsky,Stefan Uhlig,Keiji Kuba,Yumiko Imai +20 more
TL;DR: Direct regulation of the NPY–Y1R–SOCS3 pathway on phagocytes may act as a fine-tuner of an innate immune response to virus infection, which could be a therapeutic target for lethal influenza virus infection.
17
Cbl‐b regulates airway mucosal tolerance to aeroallergen
Sun Young Oh,Ju-Un Park,Tao Zheng,Yoon Keun Kim,Fan Wu,Seok Hyun Cho,Dwayne L. Barber,Josef M. Penninger,Zhou Zhu +8 more
TL;DR: Cite this as: S. Oh, J. Penninger, Z. Zhu, Clinical & Experimental Allergy, 2011 (41) 434–442.
Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies
Omar Ali,David Bomze,Lorenz Risch,Silvio D. Brugger,Matthias Paprotny,Myriam Weber,Sarah Thiel,Lukas Kern,Werner C. Albrich,Philipp Kohler,Christian R Kahlert,Pietro Vernazza,Philipp K. Buehler,Reto A. Schuepbach,Alejandro Gómez-Mejia,Alexandra Popa,Andreas Bergthaler,Josef M. Penninger,Lukas Flatz +18 more
TL;DR: Higher total IgA and IgA-aPL were consistently associated with severe illness and strongly suggest that a vigorous antiviral Ig a-response triggered in the bronchial mucosa induces systemic autoimmunity.
17
Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature
TL;DR: A novel role for Cbl-b is suggested in regulating inflammation and physiologic clearance of damaged cells in response to UVB by modulating inflammatory gene signature.
A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.
Daniel Andritschke,Sabrina Dilling,Mario Emmenlauer,Tobias Welz,Fabian Schmich,Benjamin Misselwitz,Pauli Rämö,Klemens Rottner,Eugen Kerkhoff,Teiji Wada,Josef M. Penninger,Niko Beerenwinkel,Peter Horvath,Christoph Dehio,Wolf-Dietrich Hardt +14 more
TL;DR: It is found that S. TmSipA invasion does not elicit membrane ruffles, nor promote the entry of non-invasive bacteria "in trans", however, SipA-mediated infection involved the SPIRE family of actin nucleators, besides well-established host cell factors (WRC, ARP2/3, RhoGTPases, COPI).