Josef M. Penninger
University of British Columbia
749 Papers
5.2K Citations
Josef M. Penninger is an academic researcher from University of British Columbia. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 154, co-authored 700 publications. Previous affiliations of Josef M. Penninger include Austrian Academy of Sciences & Amgen.
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Papers
JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk.
Rebecca L. Openshaw,Jaedeok Kwon,Alison McColl,Josef M. Penninger,Jonathan Cavanagh,Judith A. Pratt,Brian J. Morris +6 more
TL;DR: The results demonstrate JNK signalling as a mediator of MIA effects on the foetus as well as supporting maternal immune challenge contributing to schizophrenia-associated neurodevelopmental abnormalities.
Human CD4-Major Histocompatibility Complex Class II (DQw6) Transgenic Mice in an Endogenous CD4/CD8-deficient Background: Reconstitution of Phenotype and Human-restricted Function
Rae S. M. Yeung,Josef M. Penninger,Thomas M. Kündig,Yuk Law,Ken Yamamoto,N. Kamikawaji,Linda Burkly,Takehiko Sasazuki,Richard Flavell,Pamela S. Ohashi,Tak W. Mak +10 more
TL;DR: This animal model provides a powerful in vivo tool to dissect the human CD4-human class II MHC interaction, especially its role in human autoimmune diseases, superantigen-mediated diseases, and acquired immunodeficiency syndrome (AIDS).
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation
Qian Liu,Vsevolod Telezhkin,Wenkai Jiang,Yu Gu,Yan Wang,Wei Hong,Weiming Tian,Polina Yarova,Gaofeng Zhang,Simon Ming-Yuen Lee,Peng Zhang,Min Zhao,Nicholas D. Allen,Emilio Hirsch,Josef M. Penninger,Bing‐Fong Song +15 more
TL;DR: In this article , a 7-day physiological electric field (EF) stimulation at 100 mV/mm was used to boost the neuronal differentiation of NSCs via the PI3K/Akt/GSK-3β/β-catenin activation.
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants
Gerald Wirnsberger,Vanessa Monteil,Brett P Eaton,Elena Postnikova,Michael O. Murphy,Benedict Braunsfeld,Ian Crozier,Franz Kricek,Janine Niederhoefer,Alice Schwarzboeck,Helene Breid,Anna Sanchez Jimenez,Agnes Bugajska-Schretter,Alexander Dohnal,Christine Ruf,Romana Gugenberger,Astrid Hagelkrueys,Nuria Montserrat,Nuria Montserrat,Mike Holbrook,Chris Oostenbrink,Robert H. Shoemaker,Ali Mirazimi,Josef M. Penninger,Josef M. Penninger +24 more
TL;DR: In this article, all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, and Delta, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01).
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Stress Induces Mitochondria-mediated Apoptosis Independent of SAPK/JNK Activation in Embryonic Stem Cells
Gen Nishitai,Nao Shimizu,Takahiro Negishi,Hiroyuki Kishimoto,Kentaro Nakagawa,Daiju Kitagawa,Tomomi Watanabe,Haruka Momose,Shinya Ohata,Shuhei Tanemura,Satoshi Asaka,Junko Kubota,Ryota Saito,Hiroki Yoshida,Tak W. Mak,Teiji Wada,Josef M. Penninger,Noriyuki Azuma,Hiroshi Nishina,Toshiaki Katada +19 more
TL;DR: Results clearly show that SAPK/JNK activation is responsible for the inflammatory cytokine-induced gene expression but not essentially required for the mitochondria-dependent apoptosis at least in ES or fibroblast-like cells, which are prototypes of all cell lineages.
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