Josef M. Penninger
University of British Columbia
749 Papers
5.2K Citations
Josef M. Penninger is an academic researcher from University of British Columbia. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 154, co-authored 700 publications. Previous affiliations of Josef M. Penninger include Austrian Academy of Sciences & Amgen.
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Papers
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
Mark A. Lomaga,Wen Chen Yeh,Ildiko Sarosi,Gordon S. Duncan,Caren Furlonger,Alexandra Ho,Sean Morony,Casey Capparelli,Gwyneth Van,Stephen Kaufman,Annette Van Der Heiden,Annick Itie,Andrew Wakeham,Wilson Khoo,Takehiko Sasaki,Zhaodan Cao,Josef M. Penninger,Christopher J. Paige,David L. Lacey,Colin R. Dunstan,William J. Boyle,David V. Goeddel,Tak W. Mak +22 more
TL;DR: It is reported that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function, and it is demonstrated that TRAF6 is crucial not only in IL-1 and CD40 signaling but also, surprisingly, in LPS signaling.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Tatsuo Hashimoto,Thomas Perlot,Ateequr Rehman,Ateequr Rehman,Jean Trichereau,Hiroaki Ishiguro,Magdalena Paolino,Verena Sigl,Toshikatsu Hanada,Reiko Hanada,Simone Lipinski,Birgit Wild,Simone M. R. Camargo,Dustin Singer,Andreas Richter,Keiji Kuba,Akiyoshi Fukamizu,Stefan Schreiber,Hans Clevers,François Verrey,Philip Rosenstiel,Josef M. Penninger +21 more
TL;DR: The results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis, providing a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea.
RANKL–RANK signaling in osteoclastogenesis and bone disease
TL;DR: Designing novel drugs that target RANKL-RANK and their signaling pathways in osteoclasts could potentially revolutionize the treatment of many diseases associated with bone loss such as arthritis, tooth loss, cancer metastases or osteoporosis.
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Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
Takehiko Sasaki,Junko Irie-Sasaki,Junko Irie-Sasaki,Russell G. Jones,Antonio J. Oliveira-dos-Santos,William L. Stanford,Brad Bolon,Andrew Wakeham,Annick Itie,Dennis Bouchard,Ivona Kozieradzki,Nicholas Joza,Tak W. Mak,Tak W. Mak,Pamela S. Ohashi,Akira Suzuki,Akira Suzuki,Josef M. Penninger,Josef M. Penninger +18 more
TL;DR: It is shown that PI3Kgamma controls thymocyte survival and activation of mature T cells but has no role in the development or function of B cells.
1.1K
Autophagy in malignant transformation and cancer progression
Lorenzo Galluzzi,Federico Pietrocola,Federico Pietrocola,José Manuel Bravo-San Pedro,José Manuel Bravo-San Pedro,Ravi K. Amaravadi,Eric H. Baehrecke,Francesco Cecconi,Patrice Codogno,Jayanta Debnath,David A. Gewirtz,Vassiliki Karantza,Alec C. Kimmelman,Sharad Kumar,Beth Levine,Maria Chiara Maiuri,Maria Chiara Maiuri,Seamus J. Martin,Josef M. Penninger,Mauro Piacentini,David C. Rubinsztein,Hans-Uwe Simon,Anne Simonsen,Andrew Thorburn,Guillermo Velasco,Kevin M. Ryan,Guido Kroemer +26 more
TL;DR: The differential impact of autophagy on distinct phases of tumorigenesis is discussed and the implications of this concept for the use of Autophagy modulators in cancer therapy are discussed.
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