Josef M. Penninger
University of British Columbia
749 Papers
5.2K Citations
Josef M. Penninger is an academic researcher from University of British Columbia. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 154, co-authored 700 publications. Previous affiliations of Josef M. Penninger include Austrian Academy of Sciences & Amgen.
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Papers
Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
Sam D. Molyneux,Marco A. Di Grappa,Alexander G. Beristain,Trevor D. McKee,Daniel H. Wai,Jana Paderova,Meenakshi Kashyap,Pingzhao Hu,Tamara Maiuri,Swami R. Narala,Vuk Stambolic,Jeremy A. Squire,Josef M. Penninger,Otto Sanchez,Timothy J. Triche,Geoffrey A. Wood,Lawrence S. Kirschner,Rama Khokha +17 more
TL;DR: Using mouse genetics, it is established that Prkar1a is a bone tumor suppressor gene capable of directing subclass development and driving RANKL overexpression during OSA tumorigenesis and uncovered evidence for a PRKAR1A-low subset of human OSA with distinct clinical behavior.
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.
Rebeca Kawahara,Anastasia Chernykh,Kathirvel Alagesan,Marshall Bern,Weiqian Cao,Robert J. Chalkley,Kai Cheng,Matthew S F Choo,Nathan Edwards,Radoslav Goldman,Marcus Hoffmann,Yingwei Hu,Yifan Huang,Jin Young Kim,Doron Kletter,Benoit Liquet,Benoit Liquet,Mingqi Liu,Yehia Mechref,Bo Meng,Sriram Neelamegham,Terry Nguyen-Khuong,Jonas Nilsson,Adam Pap,Gun Wook Park,Benjamin L. Parker,Cassandra L. Pegg,Josef M. Penninger,Josef M. Penninger,Toan K. Phung,Markus Pioch,Erdmann Rapp,Enes Sakalli,Miloslav Sanda,Benjamin L. Schulz,Nichollas E. Scott,Georgy Sofronov,Johannes Stadlmann,Sergey Y. Vakhrushev,Christina M. Woo,Hung Yi Wu,Pengyuan Yang,Wantao Ying,Hui Zhang,Yong Zhang,Jingfu Zhao,Joseph Zaia,Stuart M. Haslam,Giuseppe Palmisano,Jong Shin Yoo,Göran Larson,Kai Hooi Khoo,Katalin F. Medzihradszky,Daniel Kolarich,Nicolle H. Packer,Nicolle H. Packer,Morten Thaysen-Andersen +56 more
TL;DR: In this article, a community study, comprising both developers and users of glycoproteomics software, evaluates solutions for system-wide glycopeptide analysis and concludes that diverse software packages for comprehensive glyopeptides data analysis exist, points to several high-performance search strategies and specifies key variables that will guide future software developments and assist informatics decision-making in glycoproteinomics.
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Inhibition of CBLB protects from lethal Candida albicans sepsis
Gerald Wirnsberger,Florian Zwolanek,Tomoko Asaoka,Ivona Kozieradzki,Luigi Tortola,Reiner A. Wimmer,Anoop Kavirayani,Friedrich Fresser,Gottfried Baier,Wallace Y. Langdon,Fumiyo Ikeda,Karl Kuchler,Josef M. Penninger +12 more
TL;DR: A key role for Cblb is described in the regulation of innate antifungal immunity and a novel paradigm for the treatment of fungal sepsis is established.
Vav Regulates Peptide-specific Apoptosis in Thymocytes
Young-Yun Kong,Klaus-Dieter Fischer,Martin F. Bachmann,Sanjeev Mariathasan,Ivona Kozieradzki,Mai P. Nghiem,Dennis Bouchard,Alan Bernstein,Pamela S. Ohashi,Josef M. Penninger +9 more
TL;DR: Results indicate that peptide-triggered thymocyte apoptosis is mediated via Vav activation, changes in the actin cytoskeleton, and subsequent activation of a PKC isoform.
Molecular control of bone remodeling and osteoporosis.
TL;DR: Inhibition of OPGL binding to RANK via the natural decoy receptor osteoprotegerin (OPG) prevents bone loss in postmenopausal osteoporosis and cancer metastases and completely blocks crippling in a rat model of arthritis.
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