Josée E. Leysen
VU University Medical Center
24 Papers
225 Citations
Josée E. Leysen is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 14, co-authored 24 publications. Previous affiliations of Josée E. Leysen include VU University Amsterdam & Johnson & Johnson Pharmaceutical Research and Development.
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Papers
Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions.
TL;DR: Considering the coupling of D1 and D2 receptors to the intracellular effector adenylate cyclase 5 (AC5) through their respective Gα subunits in the striatum, the data allow us to suggest that RGS2 regulates the D1/Gαolf/AC5 pathway and RGS4 the D2/G αo/AC 5 pathway.
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Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats
Gert Luurtsema,Robert C. Schuit,R. P. Klok,Joost Verbeek,Josée E. Leysen,Adriaan A. Lammertsma,Albert D. Windhorst +6 more
TL;DR: The radiosynthesis of [11C]laniquidar was developed and its suitability as a tracer of P-gp expression was assessed and it was found that [ 11C]Laniquidar could be synthesized in moderate yields with high specific activity.
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Synthesis and biodistribution of [11C]R107474, a new radiolabeled α2-adrenoceptor antagonist
M. Van der Mey,Albert D. Windhorst,R. P. Klok,Jacobus D. M. Herscheid,Ludo Edmond Josephine Kennis,François Paul Bischoff,Margot H. Bakker,Xavier Langlois,L. Heylen,Mirek Jurzak,Josée E. Leysen +10 more
TL;DR: The biodistribution of [(11)C]R107474 in rats revealed that the uptake of R107474 after in vivo intravenous administration is very rapid; in most tissues (including the brain) it reaches maximum concentration at 5 min after tracer injection.
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Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain.
Jean-Marc Taymans,C. Wintmolders,P. te Riele,Mirek Jurzak,Henk J. Groenewegen,Josée E. Leysen,Xavier Langlois +6 more
TL;DR: The localization study reveals that R GS2 mRNA and protein are widely expressed in the brain and is predominantly expressed in intrinsic striatal neurons, indicating that RGS2 is not primarily involved in the hypersensitization of postsynaptic dopamine receptors observed after lesion of the nigrostriatal pathway.
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Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand.
Anu J. Airaksinen,Jill A. Jablonowski,Margreet van der Mey,Ann J. Barbier,R. P. Klok,Joost Verbeek,Robert C. Schuit,Jacobus D. M. Herscheid,Josée E. Leysen,Nicholas I. Carruthers,Adriaan A. Lammertsma,Albert D. Windhorst +11 more
TL;DR: It appeared that [(11)C]1 could not specifically label H(3) receptors in rodent brain in vivo, and possible causes are discussed.
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