José M. C. Ribeiro

TL;DR: This work provides information into the diversity of messages expressed in the salivary glands of the tick Ixodes scapularis, describes novel sequences that may be responsible for known biological activites, indicates further biological activities that might be present in I. scAPularis saliva and identifies novel vaccine targets that may been used in Lyme disease prevention.

TL;DR: Alboserpin emerges as an atypical serpin that targets FXa and displays unique phospholipid specificity, which conceivably uses heparin and phosphatidylcholine/phosphatidylethanolamine as anchors to increase protein localization and effective concentration at sites of injury, cell activation, or inflammation.

TL;DR: In this article , the classification of tick salivary proteins under the light of the Alphafold2/Dali programs was performed, detecting novel protein families and gaining new insights relating the structure and function of tick proteins.

TL;DR: A phylogenetically broader comparative genomic analysis indicated that the most rapidly evolving proteins– those involved in immunity, hematophagy, formation of extracellular structures, and hypothetical conserved proteins– are those that probably play important roles in how mosquitoes adapt to their nutritional and external environments, and therefore could be of greatest interest in disease control.