Jose E. Castelao
University of Southern California
88 Papers
136 Citations
Jose E. Castelao is an academic researcher from University of Southern California. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 22, co-authored 55 publications. Previous affiliations of Jose E. Castelao include University Hospital Complex Of Vigo.
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Papers
Association analysis identifies 65 new breast cancer risk loci
Kyriaki Michailidou,Kyriaki Michailidou,Sara Lindström,Sara Lindström,Joe Dennis,Jonathan Beesley,Shirley Hui,Siddhartha Kar,Audrey Lemaçon,Penny Soucy,Dylan M. Glubb,Asha Rostamianfar,Manjeet K. Bolla,Qin Wang,Jonathan Tyrer,Ed Dicks,Andy C. H. Lee,Zhaoming Wang,Jamie Allen,Renske Keeman,Ursula Eilber,Juliet D. French,Xiaoqing Chen,Laura Fachal,Karen McCue,Amy E. McCart Reed,Maya Ghoussaini,Jason S. Carroll,Xia Jiang,Hilary K. Finucane,Hilary K. Finucane,Marcia Adams,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Hoda Anton-Culver,Natalia Antonenkova,Volker Arndt,Kristan J. Aronson,Banu Arun,Paul L. Auer,Paul L. Auer,Francois Bacot,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Leslie Bernstein,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Paul Brennan,Hermann Brenner,Louise A. Brinton,Per Broberg,Ian W. Brock,Annegien Broeks,Angela Brooks-Wilson,Angela Brooks-Wilson,Sara Y. Brucker,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Katja Butterbach,Qiuyin Cai,Hui Cai,Trinidad Caldés,Federico Canzian,Angel Carracedo,Brian D. Carter,Jose E. Castelao,Tsun Leung Chan,Tongguang Cheng,Kee Seng Chia,Ji Yeob Choi,Hans Christiansen,Christine L. Clarke,Margriet Collée,Don M. Conroy,Emilie Cordina-Duverger,Sten Cornelissen,David G. Cox,David G. Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Lorraine Durcan,Miriam Dwek,Diana Eccles,Arif B. Ekici,A. Heather Eliassen,A. Heather Eliassen,Carolina Ellberg,Mingajeva Elvira,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Valerie Gaborieau,Marike Gabrielson,Manuela Gago-Dominguez,Yu Tang Gao,Susan M. Gapstur,José A. García-Sáenz,Mia M. Gaudet,Vassilios Georgoulias,Graham G. Giles,Graham G. Giles,Gord Glendon,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Grethe I. Grenaker Alnæs,Mervi Grip,Jacek Gronwald,Anne Grundy,Pascal Guénel,Lothar Haeberle,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,N Hamel,Susan E. Hankinson,Patricia Harrington,Steven N. Hart,Jaana M. Hartikainen,Mikael Hartman,Mikael Hartman,Alexander Hein,Jane Heyworth,Belynda Hicks,Peter Hillemanns,Dona N. Ho,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Ming-Feng Hou,Chia-Ni Hsiung,Guanmengqian Huang,Keith Humphreys,Junko Ishiguro,Hidemi Ito,Motoki Iwasaki,Hiroji Iwata,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Arja Jukkola-Vuorinen,Rudolf Kaaks,Maria Kabisch,Katarzyna Kaczmarek,Daehee Kang,Daehee Kang,Yoshio Kasuga,Michael J. Kerin,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Johanna I. Kiiski,Sung-Won Kim,Julia A. Knight,Julia A. Knight,Veli-Matti Kosma,Vessela N. Kristensen,Vessela N. Kristensen,Ute Krüger,Ava Kwong,Diether Lambrechts,Loic Le Marchand,Eunjung Lee,Min Hyuk Lee,Jong Won Lee,Chuen Neng Lee,Flavio Lejbkowicz,Jingmei Li,Jenna Lilyquist,Annika Lindblom,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jirong Long,Artitaya Lophatananon,Artitaya Lophatananon,Jan Lubinski,Craig Luccarini,Michael P. Lux,Edmond S. K. Ma,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Enes Makalic,Kathleen E. Malone,Ivana Maleva Kostovska,Arto Mannermaa,Siranoush Manoukian,JoAnn E. Manson,JoAnn E. Manson,Sara Margolin,Shivaani Mariapun,Maria Elena Martinez,Keitaro Matsuo,Dimitrios Mavroudis,James McKay,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Primitiva Menéndez,Usha Menon,J.-P. Meyer,Hui Miao,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Kenneth Muir,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Dong-Young Noh,Børge G. Nordestgaard,Børge G. Nordestgaard,Aaron D. Norman,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Curtis Olswold,Nick Orr,V. Shane Pankratz,Sue K. Park,Sue K. Park,Tjoung-Won Park-Simon,Rachel Lloyd,Jose Ignacio Arias Perez,Paolo Peterlongo,Julian Peto,Kelly-Anne Phillips,Mila Pinchev,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Darya Prokofyeva,Elizabeth W. Pugh,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gadi Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Jane Romm,Kathryn J. Ruddy,Thomas Rüdiger,Anja Rudolph,Matthias Ruebner,Emiel J. Th. Rutgers,Emmanouil Saloustros,Dale P. Sandler,Suleeporn Sangrajrang,Elinor J. Sawyer,Daniel F. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Fredrick R. Schumacher,Peter Schürmann,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Caroline Seynaeve,Mitul Shah,Priyanka Sharma,Chen-Yang Shen,Chen-Yang Shen,Grace Sheng,Mark E. Sherman,Martha J. Shrubsole,Xiao-Ou Shu,Ann Smeets,Christof Sohn,Melissa C. Southey,John J. Spinelli,John J. Spinelli,Christa Stegmaier,Sarah Stewart-Brown,Jennifer Stone,Jennifer Stone,Daniel O. Stram,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,Rulla M. Tamimi,Jack A. Taylor,Maria Tengström,Soo Hwang Teo,Mary Beth Terry,Daniel C. Tessier,Somchai Thanasitthichai,Kathrin Thöne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ling Tong,Diana Torres,Diana Torres,Thérèse Truong,Chiu-Chen Tseng,Shoichiro Tsugane,Hans-Ulrich Ulmer,Giske Ursin,Michael Untch,Celine M. Vachon,Christi J. van Asperen,David Van Den Berg,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Rob B. van der Luijt,Daniel Vincent,Jason Vollenweider,Quinten Waisfisz,Shan Wang-Gohrke,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Anna H. Wu,Lucy Xia,Taiki Yamaji,Xiaohong R. Yang,Cheng Har Yip,Keun-Young Yoo,Jyh-Cherng Yu,Wei Zheng,Ying Zheng,Bin Zhu,Argyrios Ziogas,Elad Ziv,Sunil R. Lakhani,Sunil R. Lakhani,Antonis C. Antoniou,Arnaud Droit,Irene L. Andrulis,Irene L. Andrulis,Christopher I. Amos,Fergus J. Couch,Paul D.P. Pharoah,Jenny Chang-Claude,Jenny Chang-Claude,Per Hall,David J. Hunter,Roger L. Milne,Roger L. Milne,Montserrat Garcia-Closas,Marjanka K. Schmidt,Stephen J. Chanock,Alison M. Dunning,Stacey L. Edwards,Gary D. Bader,Georgia Chenevix-Trench,Jacques Simard,Peter Kraft,Douglas F. Easton +396 more
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
Nasim Mavaddat,Kyriaki Michailidou,Kyriaki Michailidou,Joe Dennis,Michael Lush,Laura Fachal,Andrew Lee,Jonathan Tyrer,Ting Huei Chen,Qin Wang,Manjeet K. Bolla,Xin Yang,Muriel A. Adank,Thomas U. Ahearn,Kristiina Aittomäki,Jamie Allen,Irene L. Andrulis,Irene L. Andrulis,Hoda Anton-Culver,Natalia Antonenkova,Volker Arndt,Kristan J. Aronson,Paul L. Auer,Paul L. Auer,Päivi Auvinen,Myrto Barrdahl,Laura E. Beane Freeman,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Leslie Bernstein,Carl Blomqvist,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Michael Bremer,Hermann Brenner,Adam R. Brentnall,Ian W. Brock,Angela Brooks-Wilson,Angela Brooks-Wilson,Sara Y. Brucker,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Daniele Campa,Daniele Campa,Brian D. Carter,Jose E. Castelao,Stephen J. Chanock,Rowan T. Chlebowski,Hans Christiansen,Christine L. Clarke,J. Margriet Collée,Emilie Cordina-Duverger,Sten Cornelissen,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Mary B. Daly,Peter Devilee,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Lorraine Durcan,Miriam Dwek,Diana Eccles,Arif B. Ekici,A. Heather Eliassen,A. Heather Eliassen,Carolina Ellberg,Christoph Engel,Mikael Eriksson,D. Gareth Evans,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Jonine D. Figueroa,Olivia Fletcher,Henrik Flyger,Asta Försti,Asta Försti,Lin Fritschi,Marike Gabrielson,Manuela Gago-Dominguez,Susan M. Gapstur,José A. García-Sáenz,Mia M. Gaudet,Vassilios Georgoulias,Graham G. Giles,Graham G. Giles,Graham G. Giles,I. R. Gilyazova,I. R. Gilyazova,Gord Glendon,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Grethe I. Grenaker Alnæs,Mervi Grip,Jacek Gronwald,Anne Grundy,Pascal Guénel,Lothar Haeberle,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,Susan E. Hankinson,Elaine F. Harkness,Elaine F. Harkness,Steven N. Hart,Wei He,Alexander Hein,Jane Heyworth,Peter Hillemanns,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Anthony Howell,Guanmengqian Huang,Keith Humphreys,David J. Hunter,David J. Hunter,Milena Jakimovska,Anna Jakubowska,Anna Jakubowska,Wolfgang Janni,Esther M. John,Nichola Johnson,Michael Jones,Arja Jukkola-Vuorinen,Audrey Y. Jung,Rudolf Kaaks,Katarzyna Kaczmarek,Vesa Kataja,Renske Keeman,Michael J. Kerin,Elza Khusnutdinova,Elza Khusnutdinova,Johanna I. Kiiski,Julia A. Knight,Julia A. Knight,Yon-Dschun Ko,Veli-Matti Kosma,Stella Koutros,Vessela N. Kristensen,Vessela N. Kristensen,Ute Krüger,Tabea Kühl,Diether Lambrechts,Loic Le Marchand,Eunjung Lee,Flavio Lejbkowicz,Jenna Lilyquist,Annika Lindblom,Sara Lindström,Sara Lindström,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jirong Long,Jan Lubinski,Michael P. Lux,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Enes Makalic,Ivana Maleva Kostovska,Arto Mannermaa,Siranoush Manoukian,Sara Margolin,John W.M. Martens,Maria Elena Martinez,Dimitrios Mavroudis,Catriona McLean,Alfons Meindl,Usha Menon,Pooja Middha,Pooja Middha,Nicola Miller,Fernando Salvador Moreno,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Victor Muñoz-Garzón,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,William G. Newman,Sune F. Nielsen,Børge G. Nordestgaard,Børge G. Nordestgaard,Aaron D. Norman,Kenneth Offit,Janet E. Olson,Håkan Olsson,Nick Orr,V. Shane Pankratz,Tjoung-Won Park-Simon,Jose Ignacio Arias Perez,Clara Pérez-Barrios,Paolo Peterlongo,Julian Peto,Mila Pinchev,Dijana Plaseska-Karanfilska,Eric C. Polley,Ross L. Prentice,Nadege Presneau,Darya Prokofyeva,Kristen S. Purrington,Katri Pylkäs,Brigitte Rack,Paolo Radice,Rohini Rau-Murthy,Gad Rennert,Hedy S. Rennert,Valerie Rhenius,Mark E. Robson,Atocha Romero,Kathryn J. Ruddy,Matthias Ruebner,Emmanouil Saloustros,Dale P. Sandler,Elinor J. Sawyer,Daniel F. Schmidt,Daniel F. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Fredrick R. Schumacher,Peter Schürmann,Lukas Schwentner,Christopher G. Scott,Rodney J. Scott,Rodney J. Scott,Caroline Seynaeve,Mitul Shah,Mark E. Sherman,Martha J. Shrubsole,Xiao-Ou Shu,Susan L. Slager,Ann Smeets,Christof Sohn,Penny Soucy,Melissa C. Southey,Melissa C. Southey,John J. Spinelli,Christa Stegmaier,Jennifer Stone,Jennifer Stone,Anthony J. Swerdlow,Rulla M. Tamimi,Rulla M. Tamimi,William J. Tapper,Jack A. Taylor,Mary Beth Terry,Kathrin Thöne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ian Tomlinson,Thérèse Truong,Maria Tzardi,Hans-Ulrich Ulmer,Michael Untch,Celine M. Vachon,Elke M van Veen,Joseph Vijai,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Walter C. Willett,Robert Winqvist,Alicja Wolk,Alicja Wolk,Xiaohong R. Yang,Drakoulis Yannoukakos,Yan Zhang,Wei Zheng,Argyrios Ziogas,Alison M. Dunning,Deborah J. Thompson,Georgia Chenevix-Trench,Jenny Chang-Claude,Jenny Chang-Claude,Marjanka K. Schmidt,Per Hall,Roger L. Milne,Roger L. Milne,Roger L. Milne,Paul D.P. Pharoah,Antonis C. Antoniou,Nilanjan Chatterjee,Nilanjan Chatterjee,Peter Kraft,Montserrat Garcia-Closas,Jacques Simard,Douglas F. Easton +310 more
TL;DR: This PRS, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset is developed and empirically validated and is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
Leila Dorling,Sara Carvalho,Jamie Allen,Anna González-Neira,Craig Luccarini,Cecilia Wahlström,Karen A. Pooley,Michael T. Parsons,Cristina Fortuno,Qin Wang,Manjeet K. Bolla,Joe Dennis,Renske Keeman,M. Rosario Alonso,Nuria Álvarez,Belen Herraez,Victoria Fernández,Rocio Núñez-Torres,Ana Osorio,Jeanette Valcich,Minerva Li,Therese Törngren,Patricia Harrington,Caroline Baynes,Don M. Conroy,Brennan Decker,Laura Fachal,Nasim Mavaddat,Thomas U. Ahearn,Kristiina Aittomäki,Natalia Antonenkova,Norbert Arnold,Patrick Arveux,Margreet G. E. M. Ausems,Päivi Auvinen,Heiko Becher,Matthias W. Beckmann,Sabine Behrens,Marina Bermisheva,Katarzyna Białkowska,Carl Blomqvist,Natalia Bogdanova,Nadja Bogdanova-Markov,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Hiltrud Brauch,Michael Bremer,Ignacio Briceño,Thomas Brüning,Barbara Burwinkel,David Cameron,Nicola J. Camp,Archie Campbell,Angel Carracedo,Jose E. Castelao,Melissa H. Cessna,Stephen J. Chanock,Hans Christiansen,J. Margriet Collée,Emilie Cordina-Duverger,Sten Cornelissen,Kamila Czene,Thilo Dörk,Arif B. Ekici,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Jonine D. Figueroa,Henrik Flyger,Asta Försti,Marike Gabrielson,Manuela Gago-Dominguez,Vassilios Georgoulias,Fabián Gil,Graham G. Giles,Gord Glendon,Encarna B. Gomez Garcia,Grethe I. Grenaker Alnæs,Pascal Guénel,Andreas Hadjisavvas,Lothar Haeberle,Eric Hahnen,Per Hall,Ute Hamann,Elaine F. Harkness,Jaana M. Hartikainen,Mikael Hartman,Wei He,Bernadette A M Heemskerk-Gerritsen,Peter Hillemanns,Frans B. L. Hogervorst,Antoinette Hollestelle,Weang Kee Ho,Maartje J. Hooning,Anthony Howell,Keith Humphreys,Faiza Idris,Anna Jakubowska,Audrey Y. Jung,Pooja Middha Kapoor,Michael J. Kerin,Elza Khusnutdinova,Sung-Won Kim,Yon-Dschun Ko,Veli-Matti Kosma,Vessela N. Kristensen,Kyriacos Kyriacou,Inge M. M. Lakeman,Jong Won Lee,Min Hyuk Lee,Jingmei Li,Annika Lindblom,Wing-Yee Lo,Maria A. Loizidou,Artitaya Lophatananon,Jan Lubinski,Robert J. MacInnis,Michael J. Madsen,Arto Mannermaa,Mehdi Manoochehri,Siranoush Manoukian,Sara Margolin,Maria Elena Martinez,Tabea Maurer,Dimitrios Mavroudis,Catriona McLean,Alfons Meindl,Arjen R. Mensenkamp,Kyriaki Michailidou,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Anna Marie Mulligan,Heli Nevanlinna,William G. Newman,Børge G. Nordestgaard,Pei-Sze Ng,Jan C. Oosterwijk,Sue K. Park,Tjoung-Won Park-Simon,Jose Ignacio Arias Perez,Paolo Peterlongo,David J. Porteous,Karolina Prajzendanc,Darya Prokofyeva,Paolo Radice,Muhammad Usman Rashid,Valerie Rhenius,Matti A. Rookus,Thomas Rüdiger,Emmanouil Saloustros,Elinor J. Sawyer,Rita K. Schmutzler,Andreas Schneeweiss,Peter Schürmann,Mitul Shah,Christof Sohn,Melissa C. Southey,Harald Surowy,Maija Suvanto,Somchai Thanasitthichai,Ian Tomlinson,Diana Torres,Thérèse Truong,Maria Tzardi,Yana Valova,Christi J. van Asperen,Rob M. van Dam,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Elke M van Veen,Camilla Wendt,Justin A. Williams,Xiaohong R. Yang,Sook-Yee Yoon,M. Pilar Zamora,D. Gareth Evans,Miguel de la Hoya,Jacques Simard,Antonis C. Antoniou,Åke Borg,Irene L. Andrulis,Jenny Chang-Claude,Montserrat Garcia-Closas,Georgia Chenevix-Trench,Roger L. Milne,Paul D.P. Pharoah,Marjanka K. Schmidt,Amanda B. Spurdle,Maaike P.G. Vreeswijk,Javier Benitez,Alison M. Dunning,Anders Kvist,Soo Hwang Teo,Peter Devilee,Douglas F. Easton +196 more
TL;DR: The results of this study define the genes that are most clinically useful for inclusion on panels for the prediction of breast cancer risk, as well as provide estimates of the risks associated with protein-truncating variants, to guide genetic counseling.
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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Haoyu Zhang,Haoyu Zhang,Thomas U. Ahearn,Julie Lecarpentier,Daniel R. Barnes,Jonathan Beesley,Guanghao Qi,Xia Jiang,Tracy A. O'Mara,Ni Zhao,Manjeet K. Bolla,Alison M. Dunning,Joe Dennis,Qin Wang,Zumuruda Abu Ful,Kristiina Aittomäki,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Kristan J. Aronson,Banu Arun,Paul L. Auer,Paul L. Auer,Jacopo Azzollini,Daniel Barrowdale,Heiko Becher,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Katarzyna Białkowska,Ana Blanco,Carl Blomqvist,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Bernardo Bonanni,Davide Bondavalli,Åke Borg,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Ignacio Briceño,Annegien Broeks,Sara Y Brucker,Thomas Brüning,Barbara Burwinkel,Saundra S. Buys,Helen Byers,Trinidad Caldés,Maria A. Caligo,Mariarosaria Calvello,Daniele Campa,Jose E. Castelao,Jenny Chang-Claude,Stephen J. Chanock,Melissa Christiaens,Hans Christiansen,Wendy K. Chung,Kathleen Claes,Christine L. Clarke,Sten Cornelissen,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Mary B. Daly,Peter Devilee,Orland Diez,Susan M. Domchek,Thilo Dörk,Miriam Dwek,Diana Eccles,Arif B. Ekici,D. Gareth Evans,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Lenka Foretova,Florentia Fostira,Eitan Friedman,Debra Frost,Manuela Gago-Dominguez,Susan M. Gapstur,Judy Garber,José A. García-Sáenz,Mia M. Gaudet,Simon A. Gayther,Graham G. Giles,Graham G. Giles,Graham G. Giles,Andrew K. Godwin,Mark S. Goldberg,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Mark H. Greene,Jacek Gronwald,Pascal Guénel,Lothar Häberle,Eric Hahnen,Christopher A. Haiman,Christopher R. Hake,Per Hall,Ute Hamann,Elaine F. Harkness,Elaine F. Harkness,Bernadette A M Heemskerk-Gerritsen,Peter Hillemanns,Frans B. L. Hogervorst,Bernd Holleczek,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Anthony Howell,Hanna Huebner,Peter J. Hulick,Evgeny N. Imyanitov,Claudine Isaacs,Louise Izatt,Agnes Jager,Milena Jakimovska,Anna Jakubowska,Anna Jakubowska,Paul A. James,Ramunas Janavicius,Wolfgang Janni,Esther M. John,Michael Jones,Audrey Y. Jung,Rudolf Kaaks,Pooja Middha Kapoor,Beth Y. Karlan,Renske Keeman,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Cari M. Kitahara,Yon-Dschun Ko,Irene Konstantopoulou,Linetta B. Koppert,Stella Koutros,Vessela N. Kristensen,Vessela N. Kristensen,Anne-Vibeke Lænkholm,Diether Lambrechts,Susanna C. Larsson,Susanna C. Larsson,Pierre Laurent-Puig,Conxi Lázaro,Emilija Lazarova,Flavio Lejbkowicz,Goska Leslie,Fabienne Lesueur,Annika Lindblom,Annika Lindblom,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Jennifer T. Loud,Jan Lubinski,Alicja Lukomska,Robert J. MacInnis,Robert J. MacInnis,Arto Mannermaa,Mehdi Manoochehri,Siranoush Manoukian,Sara Margolin,Maria Elena Martinez,Laura Matricardi,Lesley McGuffog,Catriona McLean,Noura Mebirouk,Alfons Meindl,Usha Menon,Austin Miller,Elvira Mingazheva,Marco Montagna,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Taru A. Muranen,Katherine L. Nathanson,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,William G. Newman,Finn Cilius Nielsen,Liene Nikitina-Zake,Jesse Nodora,Kenneth Offit,Edith Olah,Olufunmilayo I. Olopade,Olufunmilayo I. Olopade,Håkan Olsson,Håkan Olsson,Nick Orr,Laura Papi,János Papp,Tjoung-Won Park-Simon,Michael T. Parsons,Bernard Peissel,Ana Peixoto,Beth N. Peshkin,Paolo Peterlongo,J. Peto,J. Peto,Kelly-Anne Phillips,Kelly-Anne Phillips,Marion Piedmonte,Dijana Plaseska-Karanfilska,Karolina Prajzendanc,Ross L. Prentice,Darya Prokofyeva,Brigitte Rack,Paolo Radice,Susan J. Ramus,Susan J. Ramus,Johanna Rantala,Muhammad Usman Rashid,Gad Rennert,Hedy S. Rennert,Harvey A. Risch,Atocha Romero,Matti A. Rookus,Matthias Rübner,Thomas Rüdiger,Emmanouil Saloustros,Sarah Sampson,Dale P. Sandler,Elinor J. Sawyer,Maren T. Scheuner,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Ben Schöttker,Peter Schürmann,Leigha Senter,Priyanka Sharma,Mark E. Sherman,Xiao-Ou Shu,Christian F. Singer,Snezhana Smichkoska,Penny Soucy,Melissa C. Southey,John J. Spinelli,Jennifer Stone,Jennifer Stone,Dominique Stoppa-Lyonnet,Anthony J. Swerdlow,Csilla Szabo,Rulla M. Tamimi,Rulla M. Tamimi,William J. Tapper,Jack A. Taylor,Manuel R. Teixeira,M. B. Terry,Mads Thomassen,Darcy L. Thull,Marc Tischkowitz,Marc Tischkowitz,Amanda E. Toland,Rob A. E. M. Tollenaar,Ian Tomlinson,Ian Tomlinson,Diana Torres,Melissa A. Troester,Thérèse Truong,Nadine Tung,Michael Untch,Celine M. Vachon,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Elke M van Veen,Elizabeth J. van Rensburg,Ana Vega,Barbara Wappenschmidt,Clarice R. Weinberg,Jeffrey N. Weitzel,Hans Wildiers,Robert Winqvist,Alicja Wolk,Alicja Wolk,Alicja Wolk,Xiaohong R. Yang,Drakoulis Yannoukakos,Wei Zheng,Kristin K. Zorn,Roger L. Milne,Roger L. Milne,Roger L. Milne,Peter Kraft,Jacques Simard,Paul D.P. Pharoah,Kyriaki Michailidou,Kyriaki Michailidou,Antonis C. Antoniou,Marjanka K. Schmidt,Georgia Chenevix-Trench,Douglas F. Easton,Nilanjan Chatterjee,Montserrat Garcia-Closas +302 more
TL;DR: A genome-wide association study including 133,384 breast cancer cases and 113,789 controls plus 18,908 BRCA1 mutation carriers of European ancestry provides an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.
Genetic insights into biological mechanisms governing human ovarian ageing.
Katherine S. Ruth,Felix R. Day,Jazib Hussain,Ana Martínez-Marchal,Catherine E. Aiken,Ajuna Azad,Deborah J. Thompson,Lucie Knoblochova,Lucie Knoblochova,Hironori Abe,Jane L. Tarry-Adkins,Javier Martin Gonzalez,Pierre Fontanillas,Annique Claringbould,Olivier B. Bakker,Patrick Sulem,Robin G. Walters,Chikashi Terao,Sandra Turon,Momoko Horikoshi,Kuang Lin,N. Charlotte Onland-Moret,Aditya Sankar,Emil Peter Thrane Hertz,Pascal Timshel,Vallari Shukla,Rehannah Borup,Kristina W. Olsen,Kristina W. Olsen,Paula Aguilera,Paula Aguilera,Mònica Ferrer-Roda,Yan Huang,Stasa Stankovic,Paul R. H. J. Timmers,Paul R. H. J. Timmers,Thomas U. Ahearn,Behrooz Z. Alizadeh,Elnaz Naderi,Irene L. Andrulis,Irene L. Andrulis,Alice M. Arnold,Kristan J. Aronson,Annelie Augustinsson,Stefania Bandinelli,Caterina Barbieri,Robin N Beaumont,Heiko Becher,Matthias W. Beckmann,Stefania Benonisdottir,Sven Bergmann,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Stig E. Bojesen,Stig E. Bojesen,Manjeet K. Bolla,Dorret I. Boomsma,Dorret I. Boomsma,Nicholas Bowker,Jennifer A. Brody,Linda Broer,Julie E. Buring,Julie E. Buring,Archie Campbell,Harry Campbell,Jose E. Castelao,Eulalia Catamo,Stephen J. Chanock,Georgia Chenevix-Trench,Marina Ciullo,Tanguy Corre,Tanguy Corre,Fergus J. Couch,Angela Cox,Laura Crisponi,Simon S. Cross,Francesco Cucca,Francesco Cucca,Kamila Czene,George Davey Smith,Eco J. C. de Geus,Eco J. C. de Geus,Renée de Mutsert,Immaculata De Vivo,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Alison M. Dunning,Miriam Dwek,Mikael Eriksson,Tõnu Esko,Tõnu Esko,Peter A. Fasching,Peter A. Fasching,Jessica D. Faul,Luigi Ferrucci,Nora Franceschini,Timothy M. Frayling,Manuela Gago-Dominguez,Massimo Mezzavilla,Montserrat Garcia-Closas,Christian Gieger,Graham G. Giles,Graham G. Giles,Graham G. Giles,Harald Grallert,Daniel F. Gudbjartsson,Vilmundur Gudnason,Pascal Guénel,Christopher A. Haiman,Niclas Håkansson,Per Hall,Caroline Hayward,Chunyan He,Wei He,Gerardo Heiss,Miya Kudo Høffding,John L. Hopper,Jouke J. Hottenga,Jouke J. Hottenga,Frank B. Hu,Frank B. Hu,David G. Hunter,Mohammad Arfan Ikram,Rebecca D. Jackson,Micaella Joaquim,Esther M. John,Peter K. Joshi,David Karasik,Sharon L.R. Kardia,Christiana Kartsonaki,Robert Karlsson,Cari M. Kitahara,Ivana Kolcic,Charles Kooperberg,Peter Kraft,Allison W. Kurian,Zoltán Kutalik,Zoltán Kutalik,Martina La Bianca,Genevieve Lachance,Claudia Langenberg,Lenore J. Launer,Joop S.E. Laven,Debbie A Lawlor,Loic Le Marchand,Jingmei Li,Annika Lindblom,Annika Lindblom,Sara Lindström,Tricia Lindstrom,Martha S. Linet,Yongmei Liu,Simin Liu,Jian'an Luan,Reedik Mägi,Patrik K. E. Magnusson,Massimo Mangino,Massimo Mangino,Arto Mannermaa,Brumat Marco,Jonathan Marten,Nicholas G. Martin,Hamdi Mbarek,Hamdi Mbarek,Barbara McKnight,Sarah E. Medland,Christa Meisinger,Thomas Meitinger,Cristina Menni,Andres Metspalu,Lili Milani,Roger L. Milne,Roger L. Milne,Roger L. Milne,Grant W. Montgomery,Dennis O. Mook-Kanamori,Antonella Mulas,Anna Marie Mulligan,Anna Marie Mulligan,Alison D. Murray,Mike A. Nalls,Anne B. Newman,Raymond Noordam,Teresa Nutile,Dale R. Nyholt,Andrew F. Olshan,Håkan Olsson,Jodie N. Painter,Alpa V. Patel,Nancy L. Pedersen,Natalia Perjakova,Annette Peters,Ulrike Peters,Paul D.P. Pharoah,Ozren Polasek,Eleonora Porcu,Bruce M. Psaty,Iffat Rahman,Gad Rennert,Hedy S. Rennert,Paul M. Ridker,Paul M. Ridker,Susan M. Ring,Antonietta Robino,Lynda M. Rose,Frits R. Rosendaal,Jacques E. Rossouw,Igor Rudan,Rico Rueedi,Rico Rueedi,Daniela Ruggiero,Cinzia Sala,Emmanouil Saloustros,Dale P. Sandler,Serena Sanna,Elinor J. Sawyer,Chloé Sarnowski,David Schlessinger,Marjanka K. Schmidt,Minouk J. Schoemaker,Katharina E. Schraut,Katharina E. Schraut,Christopher G. Scott,Saleh Shekari,Amruta Shrikhande,Albert V. Smith,Blair H. Smith,Jennifer A. Smith,Rossella Sorice,Melissa C. Southey,Melissa C. Southey,Melissa C. Southey,Tim D. Spector,John J. Spinelli,Meir J. Stampfer,Meir J. Stampfer,Doris Stöckl,Joyce B. J. van Meurs,Konstantin Strauch,Konstantin Strauch,Unnur Styrkarsdottir,Anthony J. Swerdlow,Toshiko Tanaka,Lauren R. Teras,Alexander Teumer,Unnur Þorsteinsdottir,Unnur Þorsteinsdottir,Nicholas J. Timpson,Daniela Toniolo,Michela Traglia,Melissa A. Troester,Thérèse Truong,Jessica Tyrrell,André G. Uitterlinden,Sheila Ulivi,Celine M. Vachon,Veronique Vitart,Uwe Völker,Peter Vollenweider,Henry Völzke,Qin Wang,Nicholas J. Wareham,Clarice R. Weinberg,David R. Weir,Amber N. Wilcox,Ko Willems van Dijk,Gonneke Willemsen,Gonneke Willemsen,James F. Wilson,James F. Wilson,Bruce H. R. Wolffenbuttel,Alicja Wolk,Alicja Wolk,Andrew R. Wood,Wei Zhao,Marek Zygmunt,Zhengming Chen,Liming Li,Lude Franke,Stephen Burgess,Patrick Deelen,Patrick Deelen,Tune H. Pers,Marie Louise Grøndahl,Claus Yding Andersen,Anna Pujol,Andrés J. López-Contreras,Andrés J. López-Contreras,Jeremy A. Daniel,Kari Stefansson,Kari Stefansson,Jenny Chang-Claude,Jenny Chang-Claude,Yvonne T. van der Schouw,Kathryn L. Lunetta,Daniel I. Chasman,Daniel I. Chasman,Douglas F. Easton,Jenny A. Visser,Susan E. Ozanne,Satoshi H. Namekawa,Petr Solc,Joanne M. Murabito,Ken K. Ong,Eva Hoffmann,Anna Murray,Ignasi Roig,John R. B. Perry,John R. B. Perry +310 more
TL;DR: In this paper, the authors identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in about 200,000 women of European ancestry.
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