José Bernad
University of Toulouse
25 Papers
213 Citations
José Bernad is an academic researcher from University of Toulouse. The author has contributed to research in topics: Mannose receptor & Receptor. The author has an hindex of 15, co-authored 23 publications. Previous affiliations of José Bernad include Ministère de la Défense & Paul Sabatier University.
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Papers
The C-type Lectin Receptors Dectin-1, MR, and SIGNR3 Contribute Both Positively and Negatively to the Macrophage Response to Leishmania infantum
Lise Lefèvre,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Etienne Meunier,Alexis Valentin,David Olagnier,Hélène Authier,Carine Duval,Carine Duval,Christophe Dardenne,José Bernad,Jean Loup Lemesre,Johan Auwerx,Olivier Neyrolles,Olivier Neyrolles,Bernard Pipy,Agnès Coste +16 more
TL;DR: The macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors (CLRs) signature composed of Dectin-1, mannose receptor (MR), and the DC-SIGN homolog SIGNR3 expression, promoting CLRs as potential targets for treatment, diagnosis, and prevention of visceral leishmaniasis.
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PPARγ Promotes Mannose Receptor Gene Expression in Murine Macrophages and Contributes to the Induction of This Receptor by IL-13
Agnès Coste,Marc Dubourdeau,Marie Denise Linas,Sophie Cassaing,Jean-Claude Lepert,Patricia Balard,Sandrine Chalmeton,José Bernad,C. Orfila,J. P. Seguela,Bernard Pipy +10 more
TL;DR: It is demonstrated that the MMR expression is induced in mouse peritoneal macrophages following exposure to PPARgamma ligands or to interleukine-13 (IL-13) via a PPAR Gamma signaling pathway, and suggested that endogenous PPARGamma ligand produced by phospholipase A2 activation may be an important regulator of MMR expression by IL-13.
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PPARγ Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination
Lise Lefèvre,Amandine Galès,Amandine Galès,David Olagnier,David Olagnier,José Bernad,José Bernad,Laurence Perez,Rémy Burcelin,Alexis Valentin,Alexis Valentin,Johan Auwerx,Bernard Pipy,Bernard Pipy,Agnès Coste,Agnès Coste +15 more
TL;DR: The data demonstrate a dual benefit of PPARγ ligands because they promote mucosal defence mechanisms against GI candidiasis through M2a macrophage polarization while regulating blood glucose level.
Non-structural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase
Bureau christophe,José Bernad,Nadia Chaouche,Claudine Orfila,Maryse Boraud,Laurent Alric,Bernard Pipy,Jean-Pierre Vinel +7 more
TL;DR: Results indicate that NS3 activates NADPH oxidase and modulates ROS production, which may be involved in the natural history of hepatitis C infection.
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Biomimetic nanocrystalline apatites: Emerging perspectives in cancer diagnosis and treatment
Ahmed Al-Kattan,Sophie Girod-Fullana,Cédric Charvillat,Hélène Ternet-Fontebasso,Pascal Dufour,Jeannette Dexpert-Ghys,Veronique Santran,Julie Bordère,Bernard Pipy,José Bernad,Christophe Drouet +10 more
TL;DR: This work reports on the production and first biological evaluations of individualized luminescent nanoparticles based on Eu-doped apatites, eventually associated with folic acid, for medical imaging purposes and details the preparation of tridimensional constructs associating nanocrystalline apatite aqueous gels and drug-loaded pectin microspheres.
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