Jörg Wischhusen
University of Tübingen
31 Papers
347 Citations
Jörg Wischhusen is an academic researcher from University of Tübingen. The author has contributed to research in topics: Glioma & Programmed cell death. The author has an hindex of 24, co-authored 31 publications. Previous affiliations of Jörg Wischhusen include Free University of Berlin & University of Würzburg.
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Papers
SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells In vitro and In vivo
Martin Uhl,Steffen Aulwurm,Jörg Wischhusen,Markus Weiler,Jing Ying Ma,Ramona Almirez,Ruban Mangadu,Yu Wang Liu,Michael Platten,Ulrich Herrlinger,Alison Murphy,Darren H. Wong,Wolfgang Wick,Linda S. Higgins,Michael Weller +14 more
TL;DR: Systemic SD-208 treatment initiated 3 days after the implantation of SMA-560 cells into the brains of syngeneic VM/Dk mice prolongs their median survival from 18.6 to 25.1 days, and animals responding toSD-208 showed an increased tumor infiltration by natural killer cells, CD8 T cells, and macrophages.
435
RNA Interference Targeting Transforming Growth Factor-β Enhances NKG2D-Mediated Antiglioma Immune Response, Inhibits Glioma Cell Migration and Invasiveness, and Abrogates Tumorigenicity In vivo
Manuel A. Friese,Jörg Wischhusen,Wolfgang Wick,Markus Weiler,Günter Eisele,Alexander Steinle,Michael Weller +6 more
TL;DR: RNA interference targeting TGF-β1,2 results in a glioma cell phenotype that is more sensitive to immune cell lysis and less motile in vitro and nontumorigenic in nude mice, strongly confirming TGF -β antagonism as a major therapeutic strategy for the future treatment of malignant gliomas.
313
GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas
Patrick Roth,Patrick Roth,Markus Junker,Isabel Tritschler,Michel Mittelbronn,Yvonne Dombrowski,Samuel N. Breit,Ghazaleh Tabatabai,Ghazaleh Tabatabai,Wolfgang Wick,Michael Weller,Michael Weller,Jörg Wischhusen,Jörg Wischhusen +13 more
TL;DR: It is shown that GDF-15 at endogenous levels contributes to proliferation and immune escape of malignant gliomas in an immunocompetent host.
163
HLA-E protects glioma cells from NKG2D-mediated immune responses in vitro: implications for immune escape in vivo.
Jörg Wischhusen,Manuel A. Friese,Manuel A. Friese,Michel Mittelbronn,Richard Meyermann,Michael Weller +5 more
TL;DR: This study provides the first evidence that expression and interaction of HLA-E on cancer cells with CD94/NKG2A expressed on lymphocytes compromises innate anti-tumor immune responses.
162
Lessons from the bone marrow: How malignant glioma cells attract adult haematopoietic progenitor cells
Ghazaleh Tabatabai,Oliver Bähr,Robert Möhle,Ilker Y. Eyüpoglu,Andreas M. Boehmler,Jörg Wischhusen,Johannes Rieger,Ingmar Blümcke,Michael Weller,Wolfgang Wick +9 more
TL;DR: The molecular mechanism underlying the glioma tropism of the probably most easily accessible PC population suitable for cancer therapy, that is, adult haematopoietic PC, is defined.
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