Jörg Thömmes
Biogen Idec
16 Papers
200 Citations
Jörg Thömmes is an academic researcher from Biogen Idec. The author has contributed to research in topics: Column (database) & Chromatography detector. The author has an hindex of 9, co-authored 16 publications.
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Papers
Recent Advances in Large-Scale Production of Monoclonal Antibodies and Related Proteins
Abhinav A. Shukla,Jörg Thömmes +1 more
TL;DR: The current state-of-the-art industrial production processes, focusing on downstream technologies, for antibodies and antibody-related products are reviewed and future avenues for evolution are discussed.
617
Phase behavior of an intact monoclonal antibody.
Tangir Ahamed,Tangir Ahamed,Beatriz N.A. Esteban,Marcel Ottens,Gijs W.K. van Dedem,Luuk A.M. van der Wielen,Marc Bisschops,Albert A. Lee,Pham Christine Y,Jörg Thömmes +9 more
TL;DR: Correlating phase diagrams with B(22) data provides useful information not only for a fundamental understanding of the phase behavior of MAbs, but also for understanding the reason why certain proteins are extremely difficult to crystallize.
100
Patent
Method of purifying polypeptides by simulated moving bed chromatography
Jörg Thömmes,Alan M. Sonnenfeld,John Pieracci,Lynn Conley,Marc Bisschops,Maarten. Univalid Bioprocessing Bv Pennings +5 more
- 12 Sep 2003
TL;DR: In this paper, the authors present methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed ('SMB') system and a SMB apparatus for use in these methods.
44
Elastic net with Monte Carlo sampling for data-based modeling in biopharmaceutical manufacturing facilities
Kristen A. Severson,Jeremy G. VanAntwerp,Jeremy G. VanAntwerp,Venkatesh Natarajan,Chris Antoniou,Jörg Thömmes,Richard D. Braatz +6 more
TL;DR: A statistical modeling methodology to predict the outputs of biopharmaceutical operations is proposed, motivated by the final aim of control, regularization methods, specifically the elastic net, are combined with sampling techniques similar to the bootstrap to develop mathematical models that use only a small number of input variables.
34
Patent
Automated System and Method for Monitoring Chromatography Column Performance, and Applications Thereof
Cunnien Paul,Ganguly Joydeep,Ghosh Basav,Asif Ladiwala,Song Robert,Jörg Thömmes +5 more
- 23 Jan 2009
TL;DR: In this article, column performance is monitored by generating a plurality of process values such as conductivity values or pH values with a detector during a chromatography step transition between a first phase liquid and a second mobile phase liquid.
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