Jörg Ringel
Heidelberg University
17 Papers
225 Citations
Jörg Ringel is an academic researcher from Heidelberg University. The author has contributed to research in topics: Pancreatic disease & Pancreas. The author has an hindex of 11, co-authored 17 publications. Previous affiliations of Jörg Ringel include University of Rostock & German Cancer Research Center.
Chat about Author
Papers
•Journal Article
Mucin (MUC) Gene Expression in Human Pancreatic Adenocarcinoma and Chronic Pancreatitis: A Potential Role of MUC4 as a Tumor Marker of Diagnostic Significance
Mahefatiana Andrianifahanana,Nicolas Moniaux,Bruno M. Schmied,Jörg Ringel,Helmut Friess,Michael A. Hollingsworth,Markus W. Büchler,Jean-Pierre Aubert,Surinder K. Batra +8 more
TL;DR: It is demonstrated that pancreatic mucin MUC4 is a tumor-associated mucin, and a novel avenue to discriminate between pancreatic adenocarcinoma and pancreatitis is introduced.
Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine.
Ralf Jesnowski,Daniel Fürst,Jörg Ringel,Ying Chen,Andrea Schrödel,Jörg Kleeff,Armin Kolb,Wolfgang Schareck,Matthias Löhr +8 more
TL;DR: It is demonstrated that besides soluble factors, the matrix surrounding PSC plays a pivotal role in the maintenance of the activation process of PSC, pointing to the possibility of an antifibrosis therapy in chronic pancreatitis.
158
The MUC gene family: their role in diagnosis and early detection of pancreatic cancer.
Jörg Ringel,Matthias Löhr +1 more
TL;DR: The present knowledge about changes in the mucin gene expression in pancreatic intraepithelial neoplasia as precursor lesions and in pancreatIC adenocarcinoma, compared to normal pancreas and chronic pancreatitis is pointed out and the potential role for differentiating Chronic pancreatitis from pancreatic cancer is discussed.
Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death
Saleh M. Ibrahim,Jörg Ringel,Christian Schmidt,Bruno Ringel,Petra Müller,Dirk Koczan,Hans-Jürgen Thiesen,Matthias Löhr +7 more
TL;DR: The data suggest that pancreatic carcinoma cells have developed different mechanisms to evade the immune system, including the expression of nonfunctional receptors, decoy receptors, and molecules that block cell death, such as bcl2 and bcl-xL that could induce cell death of immune cells.
84
Aberrant Expression of a Disintegrin and Metalloproteinase 17/Tumor Necrosis Factor-α Converting Enzyme Increases the Malignant Potential in Human Pancreatic Ductal Adenocarcinoma
Jörg Ringel,Ralf Jesnowski,Ralf Jesnowski,Nicolas Moniaux,Jutta Lüttges,Jens Ringel,Amit Choudhury,Surinder K. Batra,Günter Klöppel,Matthias Löhr,Matthias Löhr +10 more
TL;DR: Findings provide evidence of aberrant expression of the proteolytically active ADAM17/TACE in advanced precursor lesions (PanIN-3) and PDAC while identifying its critical involvement in the invasion process.
70