Jörg Deiwick
Ludwig Maximilian University of Munich
8 Papers
134 Citations
Jörg Deiwick is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Virulence & Type three secretion system. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Jörg Deiwick include University of Lübeck & Free University of Berlin.
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Papers
Environmental regulation of Salmonella pathogenicity island 2 gene expression
TL;DR: It is demonstrated that SPI2 gene expression is induced by Mg2+ deprivation and phosphate starvation, which are likely to represent the environmental cues encountered by S. typhimurium inside the phagosome of infected host cells.
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Ph-dependent secretion of sseb, a product of the spi-2 type iii secretion system of salmonella typhimurium
TL;DR: It is shown that SseB is a secreted protein that associates with the surface of the bacterial cell and might, therefore, also be required for delivery of SPI‐2 effector proteins to the eukaryotic cell cytosol.
SseBCD Proteins Are Secreted by the Type III Secretion System of Salmonella Pathogenicity Island 2 and Function as a Translocon
Thomas Nikolaus,Jörg Deiwick,Catherine Rappl,Jeremy A. Freeman,Werner Schröder,Samuel I. Miller,Michael Hensel +6 more
TL;DR: The identification of a set of substrate proteins consisting of SseB, SseC, and SseD that are secreted by the SPI2 system in vitro that function as the translocon for effector proteins by intracellular Salmonella.
158
Mutations in Salmonella Pathogenicity Island 2 (SPI2) Genes Affecting Transcription of SPI1 Genes and Resistance to Antimicrobial Agents
Jörg Deiwick,Thomas Nikolaus,Jaqueline E. Shea,Colin Gleeson,David William Holden,Michael Hensel +5 more
TL;DR: It is shown that certain mutations in SPI2 affect the ability of S. typhimurium to secrete SPI1 effector proteins and to invade cultured eukaryotic cells, and that the expression of one type III secretion system can be influenced dramatically by mutations in genes encoding a second type II secretion system in the same cell.
126
Regulation of virulence genes by environmental signals in Salmonella typhimurium.
TL;DR: This work identifies environmental cues affecting the expression of genes within Salmonella Pathogenicity Island 2 (SPI2), a virulence locus important for systemic infections by S. typhimurium, and analysis of the regulation of these genes by environmental signals leading to the proteome analysis in order to define the SPI2 regulon.
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