Jordan W. Smoller
Harvard University
580 Papers
2.2K Citations
Jordan W. Smoller is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 99, co-authored 484 publications. Previous affiliations of Jordan W. Smoller include Rockefeller University & Boston Children's Hospital.
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Papers
Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization
Anna C. F. Lewis,Emma F. Perez,Anya E.R. Prince,Hana Flaxman,Lizbeth Gomez,Deanna Brockman,Paulette D. Chandler,Benjamin J. Kerman,Matthew S. Lebo,Jordan W. Smoller,Scott T. Weiss,Carrie L. Blout Zawatksy,James B. Meigs,Robert C. Green,Jason L. Vassy,Elizabeth W. Karlson +15 more
TL;DR: In this paper , patient and primary care provider responses to polygenic risk scores (PRS) clinical reporting choices have been investigated in a qualitative semi-structured interview with both patients and PCPs.
The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology.
Tian Ge,Chia-Yen Chen,Alysa E. Doyle,Alysa E. Doyle,Richard Vettermann,Lauri Tuominen,Daphne J. Holt,Mert R. Sabuncu,Jordan W. Smoller,Jordan W. Smoller +9 more
TL;DR: This work investigates the shared genetic basis between educational attainment and fine-grained cerebral cortical morphological features, and associate this genetic variation with a related aspect of cognitive ability, and executes novel statistical methods that enable high-dimensional genetic correlation analysis.
Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder
Anne J. Blood,Dan V. Iosifescu,Dan V. Iosifescu,Nikos Makris,Roy H. Perlis,David N. Kennedy,Darin D. Dougherty,Byoung Woo Kim,Myung Joo Lee,Shirley Wu,Sang Lee,Jesse Calhoun,Steven M. Hodge,Maurizio Fava,Bruce R. Rosen,Jordan W. Smoller,Gregory P. Gasic,Hans C. Breiter +17 more
TL;DR: These findings suggest that MDD may be associated with abnormal microstructure in brain reward/aversion regions, and that there may be at least two subtypes of microstructural abnormalities which each impact core symptoms of depression.
The molecular genetic landscape of human brain size variation
Jakob Seidlitz,Travis T. Mallard,Jacob W. Vogel,Younga H Lee,Varun Warrier,Gareth Ball,Oskar Hansson,Leanna M. Hernandez,Ayan Mandal,Konrad Wagstyl,Michael V. Lombardo,Eric Courchesne,Joseph T. Glessner,Theodore D. Satterthwaite,Richard A. I. Bethlehem,Shinya Tasaki,Bernard Ng,Chris Gaiteri,Jordan W. Smoller,Tian Ge,Michael J. Gandal,Aaron Alexander-Bloch +21 more
TL;DR: In this paper , the authors leverage postmortem brain RNA sequencing and estimates of brain weight (BW) in 2,531 individuals across three independent datasets, to identify 928 genes that show genome-wide significant associations with either higher or lower BW (BW+, BW-, respectively).
Testing the internal validity of the maintenance/discontinuation study design for antidepressant medications in depression using simulations
William U Meyerson,Tianxi Cai,Jordan W. Smoller,William U Meyerson,Tianxi Cai,Jordan W. Smoller +5 more
- 05 Oct 2025
TL;DR: Simulations of maintenance/discontinuation trials for antidepressant medications in depression suggest that the enrichment design, which selects remitters for continuation treatment, is sufficient to explain the larger-than-expected effect sizes, supporting the internal validity of these studies.