Joonhee Han
University of California, San Diego
4 Papers
Joonhee Han is an academic researcher from University of California, San Diego. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 4, co-authored 4 publications.
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Papers
SR Proteins in Vertical Integration of Gene Expression from Transcription to RNA Processing to Translation
TL;DR: Findings in this work highlight the broader roles of SR proteins in vertical integration of gene expression and provide mechanistic insights into their contributions to genome stability and proper cell-cycle progression in higher eukaryotic cells.
307
Pre-mRNA splicing: where and when in the nucleus
TL;DR: A new paradigm is proposed that some specific coupling events contribute to genome organization in higher eukaryotic cells by coupling RNA splicing with downstream events such as RNA export to create additional layers for regulated gene expression.
167
Alternative Splicing of a Novel Inducible Exon Diversifies the CASK Guanylate Kinase Domain
Jill A. Dembowski,Ping An,Maritsa Scoulos-Hanson,Gene W. Yeo,Joonhee Han,Xiang-Dong Fu,Paula J. Grabowski +6 more
TL;DR: It is demonstrated that a combination of a naturally defective 5′ splice site and negative regulation by several splicing factors, including SC35 and ASF/SF2 (SRSF1), drives E24a skipping in most cell types, however, this negative regulation is countered with an observed increase in E 24a inclusion after neuronal stimulation and NMDA receptor signaling.
SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons
Joonhee Han,Jian-Hua Ding,Cheol Woo Byeon,Jee H. Kim,Klemens J. Hertel,Sunjoo Jeong,Xiang-Dong Fu +6 more
TL;DR: It is shown that SR protein-induced exon skipping depends on their prevalent actions on a flanking constitutive exon and requires collaboration of more than one SR protein, and may constitute a key strategy for synergism with other splicing regulators in establishing tissue-specific alternative splicing critical for cell differentiation programs.