Joon Eoh

TL;DR: In this article, human inducedpluripotent stem cells (hiPSCs) were differentiated into early smooth muscle cells, seeded onto a hybrid poly(ethylene glycol) dimethacrylate/poly ( l -lactide) (PEGdma-PLA) scaffold and cultured in a bioreactor while exposed to pulsatile flow, towards maturation into contractile smooth muscle tissue.

TL;DR: Results indicate the accelerated test method more effectively characterized the oxidative degradation profiles than the 3% H₂O₁ treatment system, and the lack of bulk degradation in the 12-month study supports the hydrolytic stability of these PCUs.

TL;DR: 3D microfibers fabricated by hydrogel electrospinning improve extracellular matrix (ECM) deposition from vascular cells, enabling the formation of freestanding luminal multicellular microvasculature and the achievement of multicedllular microvascular structures with an organized endothelium and a robust multicesllular perivascular tunica media.

TL;DR: It is demonstrated that the vascular pathology of HIF2A GOF mutations is independent of erythrocytosis, and it is suggested that targeting these vascular aberrations could benefit patients with Hif2A GoF and conditions of augmented hypoxia signaling.