Jongrock Kong
Merck & Co.
39 Papers
213 Citations
Jongrock Kong is an academic researcher from Merck & Co.. The author has contributed to research in topics: Catalysis & Enantioselective synthesis. The author has an hindex of 14, co-authored 37 publications. Previous affiliations of Jongrock Kong include Pohang University of Science and Technology & University of Texas at Austin.
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Papers
Phosphine‐Catalyzed Regiospecific Allylic Amination and Dynamic Kinetic Resolution of Morita—Baylis—Hillman Acetates.
TL;DR: In this article, a chiral racemic MBH acetate 4 was converted to the corresponding allylic amination product in 80% yield and 56% enantiomeric excess, thus establishing the feasibility of dynamic kinetic resolution.
Hydrogen-Mediated Reductive Coupling of Conjugated Alkynes with Ethyl (N-Sulfinyl)iminoacetates: Synthesis of Unnatural α-Amino Acids via Rhodium-Catalyzed C−C Bond Forming Hydrogenation
TL;DR: These studies represent the first use of imines as electrophilic partners in hydrogen-mediated reductive carbon-carbon bond formation with exceptional levels of regioselective reduction and stereocontrol.
145
Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for covid-19
John A. McIntosh,Tamas Benkovics,Steven M. Silverman,Mark A. Huffman,Jongrock Kong,Peter E. Maligres,Tetsuji Itoh,Hao Yang,Deeptak Verma,Weilan Pan,Hsing-I Ho,Jonathan Vroom,Anders M. Knight,Jessica A. Hurtak,Artis Klapars,Anna Fryszkowska,William J. Morris,Neil A. Strotman,Grant S. Murphy,Kevin M. Maloney,Patrick S. Fier +20 more
TL;DR: In this paper, a short and sustainable synthesis of molnupiravir (MK-4482) from simple raw materials that would minimize the time needed to manufacture and supply moln upiravirus was proposed, enabled by the invention of a novel biocatalytic cascade featuring an engineered ribosyl-1kinase and uridine phosphorylase.
138
Catalytic Carbonyl Z-Dienylation via Multicomponent Reductive Coupling of Acetylene to Aldehydes and α-Ketoesters Mediated by Hydrogen: Carbonyl Insertion into Cationic Rhodacyclopentadienes
Jongrock Kong,Michael J. Krische +1 more
TL;DR: These multicomponent couplings represent the first use of acetylene gas, a basic chemical feedstock, in metal-catalyzed reductive C-C bond formation.
125
ESI-MS, DFT, and synthetic studies on the H2-mediated coupling of acetylene: Insertion of C=X bonds into rhodacyclopentadienes and Brønsted acid cocatalyzed hydrogenolysis of organorhodium intermediates
Vanessa M. Williams,Jongrock Kong,Byoung Joon Ko,Yogita Mantri,Jennifer S. Brodbelt,Mu Hyun Baik,Michael J. Krische +6 more
TL;DR: Computer model studies based on density functional theory (DFT) support the proposed mechanism and identify Brønsted acid cocatalyst assisted hydrogenolysis to be the most difficult step and provide new insight into the reactivity of cationic rhodacyclopentadienes, which should facilitate the design of related rhodium-catalyzed C-C couplings.
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