JongDae Shin
University of Massachusetts Medical School
11 Papers
1 Citations
JongDae Shin is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: X-inactivation & XIST. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of JongDae Shin include Konyang University.
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Papers
Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice
JongDae Shin,Michael Bossenz,Michael Bossenz,Young Min Chung,Hong Ma,Meg Byron,Naoko Taniguchi-Ishigaki,Xiaochun Zhu,Xiaochun Zhu,Baowei Jiao,Lisa L. Hall,Michael R. Green,Michael R. Green,Stephen N. Jones,Irm Hermans-Borgmeyer,Jeanne B. Lawrence,Ingolf Bach +16 more
TL;DR: It is shown that the maternal transmission of the mutant X chromosome (Δm) leads to lethality in female embryos as a result of defective imprinted XCI, and evidence is provided that in Δm female embryos the initial formation of Xist clouds and Xp silencing are inhibited.
RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast.
JongDae Shin,Mary C. Wallingford,Judith Gallant,Chelsea Marcho,Baowei Jiao,Meg Byron,Michael Bossenz,Jeanne B. Lawrence,Stephen N. Jones,Jesse Mager,Ingolf Bach +10 more
TL;DR: It is demonstrated that female cells lacking RLIM from pre-implantation stages onwards show hallmarks of XCI, including Xist clouds and H3K27me3 foci, and have full embryogenic potential, indicating that in mice an RLIM-independent mechanism activates Xist in the embryo proper.
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Regulation of X-linked gene expression during early mouse development by Rlim
Feng Wang,JongDae Shin,JongDae Shin,Jeremy M. Shea,Jun Yu,Ana Bošković,Meg Byron,Xiaochun Zhu,Alex K. Shalek,Aviv Regev,Jeanne B. Lawrence,Eduardo M. Torres,Lihua Julie Zhu,Oliver J. Rando,Ingolf Bach +14 more
TL;DR: It is found that X/A upregulation is initiated in early male and female preimplantation embryos and crucial roles of Rlim for the maintenance of high Xist RNA levels, Xist clouds and X-silencing in female embryos at blastocyst stages are revealed.
Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis
Daewon Han,Haeil Kim,Soojin Kim,Qui Anh Le,S. Han,Jeongyun Bae,Hye Won Shin,Hyun-Goo Kang,Kyung Ho Han,JongDae Shin,Hwan-Woo Park +10 more
TL;DR: In this article , the role of hepatic Sestrin2 in cholestatic liver injury and its underlying mechanisms using in vivo and in vitro approaches was investigated. But the authors did not consider the effect of bile acid in the liver due to impaired bile flow.
Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs.
Feng Wang,Kurtis N. McCannell,Ana Bošković,Xiaochun Zhu,JongDae Shin,Jun Yu,Judith Gallant,Meg Byron,Jeanne B. Lawrence,Lihua Julie Zhu,Stephen N. Jones,Oliver J. Rando,Thomas G. Fazzio,Ingolf Bach +13 more
TL;DR: Rlim-dependent and Rlim-independent pathways for rXCI in differentiating female ESCs are demonstrated and uncoupling these pathways is found to find more efficient XCI in ESCs cultured under physiological oxygen conditions.
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