Jong-Won Kim
Samsung Medical Center
357 Papers
1.8K Citations
Jong-Won Kim is an academic researcher from Samsung Medical Center. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 39, co-authored 351 publications. Previous affiliations of Jong-Won Kim include Sungkyunkwan University & Samsung.
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Papers
Inferring pathway activity toward precise disease classification.
TL;DR: It is shown that classifiers using pathway activity achieve better performance than classifiers based on individual gene expression, for both simple and complex case-control studies including differentiation of perturbed from non-perturbed cells and subtyping of several different kinds of cancer.
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome
Mi-Ae Jang,Eun Kyoung Kim,Hesung Now,Nhung Thi-Cam Nguyen,Woo-Jong Kim,Joo-Yeon Yoo,Jinhyuk Lee,Jinhyuk Lee,Yun-Mi Jeong,Cheol-Hee Kim,Ok Hwa Kim,Seongsoo Sohn,Seong-Hyeuk Nam,Yoojin Hong,Yong-seok Lee,Sung-A Chang,Shin Yi Jang,Jong-Won Kim,Myung-Shik Lee,So Young Lim,Ki-Sun Sung,Ki-Tae Park,Byoung Joon Kim,Joo-Heung Lee,Duk-Kyung Kim,Changwon Kee,Chang-Seok Ki +26 more
TL;DR: It is demonstrated that DDX58 mutations cause atypical SMS manifesting with variable expression of glaucoma, aortic calcification, and skeletal abnormalities without dental anomalies.
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SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
Akinori Miyashita,Asako Koike,Gyungah Jun,Li-San Wang,Satoshi Takahashi,Etsuro Matsubara,Takeshi Kawarabayashi,Mikio Shoji,Naoki Tomita,Hiroyuki Arai,Takashi Asada,Yasuo Harigaya,Masaki Ikeda,Masakuni Amari,Haruo Hanyu,Susumu Higuchi,Takeshi Ikeuchi,Masatoyo Nishizawa,Masaichi Suga,Yasuhiro Kawase,Hiroyasu Akatsu,Kenji Kosaka,Takayuki Yamamoto,Masaki Imagawa,Tsuyoshi Hamaguchi,Masahito Yamada,Takashi Moriaha,Masatoshi Takeda,Takeo Takao,Kenji Nakata,Yoshikatsu Fujisawa,Ken Sasaki,Ken Watanabe,Kenji Nakashima,Katsuya Urakami,Terumi Ooya,Mitsuo Takahashi,Takefumi Yuzuriha,Kayoko Serikawa,Seishi Yoshimoto,Ryuji Nakagawa,Jong-Won Kim,Chang-Seok Ki,Hong-Hee Won,Duk L. Na,Sang Won Seo,Inhee Mook-Jung,Peter St George-Hyslop,Richard Mayeux,Jonathan L. Haines,Margaret A. Pericak-Vance,Makiko Yoshida,Nao Nishida,Katsushi Tokunaga,Ken Yamamoto,Shoji Tsuji,Ichiro Kanazawa,Yasuo Ihara,Gerard D. Schellenberg,Lindsay A. Farrer,Ryozo Kuwano +60 more
TL;DR: Genome-wide significance of LOAD with SORL1 is demonstrated for the first time and the role of other known loci for LOAD in Japanese is confirmed and highlights the importance of examining associations in multiple ethnic populations.
Identification and validation of SAA as a potential lung cancer biomarker and its involvement in metastatic pathogenesis of lung cancer.
Hye-Jin Sung,Jung-Mo Ahn,Yeon-Hee Yoon,Taiyoun Rhim,Choon-Sik Park,Jae Yong Park,Soo-Youn Lee,Jong-Won Kim,Je-Yoel Cho +8 more
TL;DR: The data suggest that a higher concentration of SAA can serve as an indicator of lung adenocarcinoma and represents a therapeutic target for the inhibition of lung cancer metastasis.
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