Jong Seong Im
6 Papers
1 Citations
Jong Seong Im is an academic researcher. The author has contributed to research in topics: Filtration & Chemistry. The author has an hindex of 1, co-authored 1 publications.
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Papers
A programmable encapsulation system improves delivery of therapeutic bacteria in mice
Tetsuhiro Harimoto,Jaeseung Hahn,Yu-Yu Chen,Jong Seong Im,Joanna Zhang,Nicholas Hou,Fang-fang Li,Courtney Coker,Kelsey E. Gray,Nicole Harr,Sreyan Chowdhury,Kelly Pu,Clare A. Nimura,Nicholas Arpaia,Kam W. Leong,Tal Danino +15 more
TL;DR: In this article , a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular polysaccharides was developed to enhance systemic delivery of living bacteria therapies for treating a broad array of cancers.
Probiotic-guided CAR-T cells for solid tumor targeting
Rosa Vincent,Candice Gurbatri,Fang-fang Li,Ana Vardoshvili,Courtney Coker,Jong Seong Im,Edward R. Ballister,Mathieu Rouanne,Thomas Savage,Kenia de Los Santos-Alexis,Andrew Redenti,Leonie Brockmann,Meghna Komaranchath,Nicholas Arpaia,Tal Danino +14 more
TL;DR: A platform of probiotic-guided CAR-T cells (ProCARs), in which tumor-colonizing probiotics release synthetic targets that label tumor tissue for CAR-mediated lysis in situ, demonstrated safe and effective in multiple xenograft and syngeneic models of human and mouse cancers.
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Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Candice Gurbatri,Georgette Radford,Laura Vrbanac,Jong Seong Im,Elaine M. Thomas,Courtney Coker,Samuel R Taylor,YoungUk Jang,Ayelet Sivan,Kyu Rhee,Anas A. Saleh,Tiffany Chien,Fereshteh Zandkarimi,Ioana Lia,Tamsin R M Lannagan,Tongtong Wang,Josephine A. Wright,Hiroki Kobayashi,Jia Q Ng,Matt Lawrence,Tarik Sammour,Michelle Thomas,Lito E. Papanicolas,Joanne Perry,Tracy Fitzsimmons,Patricia Kaazan,Amanda Lim,Alexandra M. Stavropoulos,Dion A. Gouskos,Julie Marker,Cheri Ostroff,Geraint Rogers,Nicholas Arpaia,Daniel L. Worthley,Susan L. Woods,Tal Danino +35 more
TL;DR: It is shown that orally administered E. coli Nissle 1917 can selectively colonize adenomas in mouse models and in patients as a detection tool, as well as deliver immunotherapeutics for colorectal neoplasia treatment.
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Bacterial therapies at the interface of synthetic biology and nanomedicine
Jaeseung Hahn,Suwan Ding,Jong Seong Im,Tetsuhiro Harimoto,Kam W. Leong,Tal Danino +5 more
TL;DR: Recent progress in nanobiotechnology-driven engineering of bacteria-based therapies is reviewed, highlighting limitations and opportunities that will facilitate clinical translation.
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