5 Papers
30 Citations
Jong-Han Kim is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Farnesyl Protein Transferase & Cell culture. The author has an hindex of 3, co-authored 5 publications.
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Papers
Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents.
Dae-Seop Shin,Jong-Han Kim,Su-Kyung Lee,Dong Cho Han,Kwang-Hee Son,Hwan-Mook Kim,Hyae-Gyeong Cheon,Kwang-Rok Kim,Nack-Do Sung,Seung-Jae Lee,Sung Kwon Kang,Byoung-Mog Kwon +11 more
TL;DR: It was found that 2-piperazine derivative blocked in vivo growth of human colon tumor xenograft in nude mice at 10 mg/kg and their anti-tumor effects induce apoptosis and cell cycle arrest at G2/M phase by the compounds.
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Relationship between flavonoid structure and inhibition of farnesyl protein transferase
Hyun-Mi Kang,Jong-Han Kim,Mi-Young Lee,Kwang-Hee Son,Deok Cho Yang,Nam-In Baek,Byoung-Mog Kwon +6 more
TL;DR: The studies of structure-FPTase inhibitory activity indicated that the number, position and substitution of hydroxyl groups of the A and B rings of flavonoid, and unsaturation of the C2–C3 bond are important factors affecting inhibition on FPTase by flavonoids.
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Synthesis and Ligand Based 3D-QSAR of 2,3-Bis-benzylidenesuccinaldehyde Derivatives as New Class Potent FPTase Inhibitor, and Prediction of Active Molecules
TL;DR: It is suggested that the structural distinctions and descriptors that contribute to inhibitory activities (pI50) against FPTase will be able to applied new inhibitor design.
Patent
Artemisolide compound isolated from the aerial parts of Artemisia sylvatica, isolation method, and use thereof
Byoung-Mog Kwon,Kwang-Hee Son,Dong-Choi Han,Jong-Han Kim,Hyun-Mi Kang,Jun Sun Bok +5 more
- 28 Jan 2003
TL;DR: In this paper, a novel compound isolated from Artemisia sylvatica, expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to inhibit farnesyl transferase activity, which is essential for activating Ras oncogene and repressing cancer cell growth.
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Synthesis and Ligand Based 3D-QSAR of 2,3-Bis-benzylidenesuccinaldehyde Derivatives as New Class Potent FPTase Inhibitor, and Prediction of Active Molecules.
TL;DR: In this paper, a series of 2,3-bis-benzylidenesuccinaldehyde derivatives (1-29) were synthesized and their inhibition activities (pI50) against FPTase were measured.
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