Jong Eun Lee
Ewha Womans University
4 Papers
Jong Eun Lee is an academic researcher from Ewha Womans University. The author has contributed to research in topics: Fusion gene & Gene expression profiling. The author has an hindex of 4, co-authored 4 publications.
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Papers
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma
Hae Yong Yoo,Min Kyung Sung,Seung Ho Lee,Sangok Kim,Haeseung Lee,Seong-Jin Park,Sang Cheol Kim,Byungwook Lee,Kyoohyoung Rho,Jong Eun Lee,Kwang-Hwi Cho,Wankyu Kim,Hyunjung Ju,Jaesang Kim,Seok Jin Kim,Won Seog Kim,Sanghyuk Lee,Young Hyeh Ko +17 more
TL;DR: A frequent somatic mutation in RHOA is reported using exome and transcriptome sequencing of samples from individuals with AITL and it is demonstrated that the RHOA mutation encoding p.Gly17Val is oncogenic in nature using multiple molecular assays.
372
Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing
Yeonjoo Jung,Pora Kim,Yeonhwa Jung,Juhee Keum,Soon Kim,Yong Soo Choi,In Gu Do,Jinseon Lee,So Jung Choi,Su Jin Kim,Jong Eun Lee,Jhingook Kim,Sanghyuk Lee,Jaesang Kim +13 more
TL;DR: This study confirms the utility of next generation sequencing as a tool for the discovery of somatic mutations and has led to the identification of a novel mutation in NSCLC that may be of diagnostic, prognostic, and therapeutic importance.
98
A high-dimensional, deep-sequencing study of lung adenocarcinoma in female never-smokers.
Sang Cheol Kim,Yeonjoo Jung,Jinah Park,Sooyoung Cho,Chaehwa Seo,Jaesang Kim,Pora Kim,Jehwan Park,Jihae Seo,Jihae Seo,Jiwoong Kim,Seong-Jin Park,Insu Jang,Namshin Kim,Jin Ok Yang,Byungwook Lee,Kyoohyoung Rho,Yeonhwa Jung,Juhee Keum,Jinseon Lee,Jungho Han,Sangeun Kang,Sujin Bae,So Jung Choi,Su Jin Kim,Jong Eun Lee,Wankyu Kim,Jhingook Kim,Sanghyuk Lee,Sanghyuk Lee +29 more
TL;DR: The most prominent gene network module that emerged indicates that disturbances in G2/M transition and mitotic progression are causally linked to tumorigenesis in these patients, and results from the analysis strongly suggest that several novel microRNA-target interactions represent key regulatory elements of the gene network.
84
Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma
Hae Yong Yoo,Pora Kim,Won Seog Kim,Seung Ho Lee,Sangok Kim,So Young Kang,Hye Yoon Jang,Jong Eun Lee,Jaesang Kim,Seok Jin Kim,Young Hyeh Ko,Sanghyuk Lee +11 more
TL;DR: The gene fusion, which codes for the extracellular domain of CTLA4 and the cytoplasmic region of CD28, is likely capable of transforming inhibitory signals into stimulatory signals for T-cell activation and represents a potential target for anti-CTLA4 cancer immunotherapy.