Jonathan Wilhelm
University of Texas Southwestern Medical Center
12 Papers
2 Citations
Jonathan Wilhelm is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Chemistry & Cancer immunotherapy. The author has an hindex of 5, co-authored 7 publications.
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Papers
Prolonged activation of innate immune pathways by a polyvalent STING agonist
Suxin Li,Min Luo,Zhaohui Wang,Qiang Feng,Jonathan Wilhelm,Xu Wang,Li Wei,Jian Wang,Agnieszka Cholka,Yang Xin Fu,Baran D. Sumer,Hongtao Yu,Hongtao Yu,Jinming Gao +13 more
TL;DR: In this article, a polyvalent STING agonist, a pH-sensitive polymer bearing a seven-membered ring with a tertiary amine (PC7A), was shown to stimulate the production of pro-inflammatory cytokines by binding to a noncompetitive STING surface site.
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Tumor-Targeted Inhibition of Monocarboxylate Transporter 1 Improves T-Cell Immunotherapy of Solid Tumors.
Tongyi Huang,Qiang Feng,Zhaohui Wang,Li Wei,Zhichen Sun,Jonathan Wilhelm,Gang Huang,Tram Vo,Baran D. Sumer,Jinming Gao +9 more
TL;DR: Data illustrate that tumor‐targeted inhibition of MCT1 can reverse the immune suppressive microenvironment of solid tumors for increased safety and antitumor efficacy of cancer immunotherapy.
71
Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window.
Xu Wang,Jonathan Wilhelm,Li Wei,Suxin Li,Zhaohui Wang,Gang Huang,Jian Wang,Houliang Tang,Sina Khorsandi,Zhichen Sun,Bret M. Evers,Jinming Gao +11 more
TL;DR: A series of degradable ultra-pH sensitive (dUPS) polymers that amplify small acidic pH changes to efficacious therapeutic outputs are reported that open up opportunities in pH-targeted drug and protein therapy.
Transistor-like Ultra-pH-Sensitive Polymeric Nanoparticles
TL;DR: The inception and implementation of a "proton transistor" nanoparticle that can digitize acidotic pH signals in biological systems is highlighted and the rational design and development of additional transistor-like chemical sensors to digitize analog biological signals are promoted.
Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy
Xiaoyi Jiang,Jiyang Wang,Xichen Zheng,Zhida Liu,Xinyu Zhang,Yu-wei Li,Jonathan Wilhelm,Jun Cao,Gang Huang,Jinlan Zhang,Baran D. Sumer,Jayanthi S. Lea,Zhigang Lu,Jinming Gao,Min Luo +14 more
TL;DR: Mechanistic investigation revealed that intratumoral administration of the nanovaccine significantly increased the infiltration of antigen-specific T cells in TC-1 tumors, despite the lower systemic levels of T cells compared with subcutaneous injection.