Jonathan Tabak
5 Papers
15 Citations
Jonathan Tabak is an academic researcher. The author has contributed to research in topics: DNA profiling & Cancer. The author has an hindex of 4, co-authored 5 publications.
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Papers
DNA and RNA profiling of excavated human remains with varying postmortem intervals.
TL;DR: Not only DNA but also RNA molecules can be remarkably stable and used for profiling of long-buried human remains, which corroborate forensic applications and change sampling policies in identification cases of degrading cadavers.
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Optimizing DNA recovery and forensic typing of degraded blood and dental remains using a specialized extraction method, comprehensive qPCR sample characterization, and massively parallel sequencing
Patricio Carrasco,Carolina Inostroza,Meghan Didier,Marianela Godoy,Cydne Holt,Jonathan Tabak,Andrew Loftus +6 more
TL;DR: Initial evaluation of artificially degraded blood samples achieved highly sensitive and informative quantification results with InnoQuant® HY, enabling successful first pass genotyping with the MiSeq FGx® System, indicating successful performance of the proposed workflow from degraded DNA from teeth samples.
Development and validation of InnoQuant® HY, a system for quantitation and quality assessment of total human and male DNA using high copy targets
Andrew Loftus,Gina Murphy,Hiromi Brown,Anne H. Montgomery,Jonathan Tabak,James Baus,Marion Carroll,Andre’ Green,Suresh C. Sikka,Sudhir K. Sinha +9 more
TL;DR: The experimental results demonstrate InnoQuant HY as a robust qPCR method producing accurate DNA quantitation results even at low dynamic ranges, with reproducibility among population groups, and provides a tool equipping a forensic analyst with crucial data about a sample'sDNA quantitation, male:female ratio, degradation state, and the presence or absence of PCR inhibitors.
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Retrotransposable elements: Novel and sensitive DNA markers and their application in human identity
Sudhir K. Sinha,Gina Murphy,Hiromi Brown,Andre’ Green,Anne H. Montgomery,Marion Carrol,Jonathan Tabak +6 more
TL;DR: This is the first time any research on the use of retrotransposable elements for human identity applications has been conducted, and it is shown that REs are more stable than other systems in terms of inheritance.
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Multiplexed real-time polymerase chain reaction cell-free DNA assay as a potential method to monitor stage IV colorectal cancer.
Sudhir K. Sinha,Hiromi Brown,Jonathan Tabak,Zhide Fang,Mathilde Couetoux du Tertre,Susan McNamara,Karen Gambaro,Gerald Batist,Joseph F. Buell +8 more
TL;DR: The multiplexed real-time polymerase chain reaction measurements of retro-transposable elements in cancer patient plasma potentially possess the ability to monitor therapy responsiveness in near real time.