Jonathan Schulz
University of Texas MD Anderson Cancer Center
10 Papers
7 Citations
Jonathan Schulz is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Chromatin & Enhancer. The author has an hindex of 2, co-authored 10 publications. Previous affiliations of Jonathan Schulz include University of Texas Health Science Center at Houston.
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Papers
Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer.
Elias Orouji,Ayush T. Raman,Anand K Singh,Alexey V. Sorokin,Emre Arslan,Archit K. Ghosh,Jonathan Schulz,Christopher Terranova,Shan Jiang,Ming Tang,Mayinuer Maitituoheti,Scot C Callahan,Praveen Barrodia,Katarzyna Tomczak,Yingda Jiang,Zhi-Qin Jiang,Jennifer S. Davis,Sukhen C. Ghosh,Hey Min Lee,Laura Reyes-Uribe,Kyle Chang,Yusha Liu,Huiqin Chen,Ali Azhdarinia,Jeffrey S. Morris,Eduardo Vilar,Kendra S. Carmon,Scott Kopetz,Kunal Rai +28 more
TL;DR: In this article, the authors performed comprehensive epigenomic characterisation by mapping 222 chromatin profiles from 69 samples (33 colorectal adenocarcinomas, 4 adenomas, 21 matched normal tissues and 11 colon cancer cell lines) for six histone modification marks.
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Machine Learning in Epigenomics: Insights into Cancer Biology and Medicine
TL;DR: In this paper, the authors discuss four overlapping but distinct major categories under ML: dimensionality reduction, unsupervised methods, supervised methods, and deep learning (DL) for cancer epigenomics data.
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Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state
Veena Kochat,Ayush T. Raman,Ayush T. Raman,Ayush T. Raman,Sharon M. Landers,Ming Tang,Ming Tang,Jonathan Schulz,Christopher Terranova,Jace P. Landry,Jace P. Landry,Angela D. Bhalla,Hannah C. Beird,Chia Chin Wu,Yingda Jiang,Xizeng Mao,Rossana Lazcano,Swati Gite,Davis R. Ingram,Min Yi,Jianhua Zhang,Emily Z. Keung,Christopher P. Scally,Christina L. Roland,Kelly K. Hunt,Barry W. Feig,P. Andrew Futreal,Patrick Hwu,Wei Lien Wang,Alexander J. Lazar,John M. Slopis,Heather Wilson-Robles,Dominique J Wiener,Ian E. McCutcheon,Brandan G Wustefeld-Janssens,Brandan G Wustefeld-Janssens,Kunal Rai,Kunal Rai,Keila E. Torres +38 more
TL;DR: In this paper, a dedifferentiated early neural-crest phenotype was found in polycomb repressor complex 2 (PRC2) mutants of malignant peripheral nerve sheath tumors (MPNSTs) and was validated via cross-species comparative analysis using spontaneous and transgenic MPNST models.
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Bivalent and Broad Chromatin Domains Regulate Pro-metastatic Drivers in Melanoma
Christopher Terranova,Ming Tang,Mayinuer Maitituoheti,Ayush T. Raman,Ayush T. Raman,Ayush T. Raman,Jonathan Schulz,Samir B. Amin,Elias Orouji,Katarzyna Tomczak,Sharmistha Sarkar,Junna Oba,Caitlin Creasy,Chang-Jiun Wu,Dongyu Zhao,Kaifu Chen,Lauren E. Haydu,Wei-Lien Wang,Alexander J. Lazar,Scott E. Woodman,Chantale Bernatchez,Kunal Rai +21 more
TL;DR: It is proposed that specific epigenetic traits – such as bivalent and broad domains – get assimilated in the epigenome of pro-metastatic clones to drive evolution of cancer cells to metastasis.
KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment
S. Carson Callahan,Margarita Divenko,Praveen Barrodia,Anand K Singh,Emre Arslan,Zhiyi Liu,Jiah Yang,Nazanin Esmaeili Anvar,Moran Amit,Tongxin Xie,Shan Jiang,Jonathan Schulz,Ming Tang,Ming Tang,Ming Tang,Jeffrey N. Myers,Kunal Rai +16 more
TL;DR: In this paper, the role of KMT2D as a tumor suppressor in head and neck squamous cell carcinoma (HNSCC) has been investigated and shown to be associated with 2-year recurrence in TCGA data.