Glucose control and vascular complications in veterans with type 2 diabetes

Authors/Task Force Members: Massimo F. Piepoli* (Chairperson) (Italy), Arno W. Hoes* (Co-Chairperson) (The Netherlands), Stefan Agewall (Norway)1, Christian Albus (Germany)9, Carlos Brotons (Spain)10, Alberico L. Catapano (Italy)3, Marie-Therese Cooney (Ireland)1, Ugo Corrà (Italy)1, Bernard Cosyns (Belgium)1, Christi Deaton (UK)1, Ian Graham (Ireland)1, Michael Stephen Hall (UK)7, F. D. Richard Hobbs (UK)10, Maja-Lisa Løchen (Norway)1, Herbert Löllgen (Germany)8, Pedro Marques-Vidal (Switzerland)1, Joep Perk (Sweden)1, Eva Prescott (Denmark)1, Josep Redon (Spain)5, Dimitrios J. Richter (Greece)1, Naveed Sattar (UK)2, Yvo Smulders (The Netherlands)1, Monica Tiberi (Italy)1, H. Bart van der Worp (The Netherlands)6, Ineke van Dis (The Netherlands)4, W. M. Monique Verschuren (The Netherlands)1

http://kidneys.zaslavsky.com.ua/article/download/84325/116293

Європейське керівництво з профілактики серцево-судинних захворювань у клінічній практиці — 2016

Effect of Torcetrapib on the Progression of Coronary Atherosclerosis

Hydrolysis of platelet-activating factor by human serum paraoxonase

Numerous studies have reported the presence of oxidatively modified high-density lipoprotein (OxHDL) within the intima of atheromatous plaques as well as in plasma; however, its role in the pathogenesis of thrombotic disease is not established. We now report that OxHDL, but not native HDL, is a potent inhibitor of platelet activation and aggregation induced by physiologic agonists. This antithrombotic effect was concentration and time dependent and positively correlated with the degree of lipoprotein oxidation. Oxidized lipoproteins are known ligands for scavenger receptors type B, CD36 and scavenger receptor B type I (SR-BI), both of which are expressed on platelets. Studies using murine CD36(-/-) or SR-BI(-/-) platelets demonstrated that the antithrombotic activity of OxHDL depends on platelet SR-BI but not CD36. Binding to SR-BI was required since preincubation of human and murine platelets with anti-SR-BI blocking antibody abrogated the inhibitory effect of OxHDL. Agonist-induced aggregation of platelets from endothelial nitric oxide synthase (eNOS)(-/-), Akt-1(-/-), and Akt-2(-/-) mice was inhibited by OxHDL to the same degree as platelets from wild-type (WT) mice, indicating that the OxHDL effect is mediated by a pathway different from the eNOS/Akt pathway. These novel findings suggest that contrary to the prothrombotic activity of oxidized low-density lipoprotein (OxLDL), HDL upon oxidation acquires antithrombotic activity that depends on platelet SR-BI.

Oxidized high‐density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI

.............................................................................. 10 Declaration............................................................................ 12 Copyright Statement ................................................................ 13 Rationale for Submitting Thesis in Alternative Format ...................... 14 Acknowledgement................................................................... 15 Academic Work Published during Registration ................................ 16 Abstracts Presented during Registration........................................ 17s Presented during Registration........................................ 17 Introduction .......................................................................... 19 Methodology .......................................................................... 21 1. High-density Lipoprotein Cholesterol Raising: Does it Matter? ......... 51 Figures and Tables........................................................................ 60 Published Version ........................................................................64 2. A Review of Paradoxical HDL-C Responses to Fenofibrate, Illustrated by a Case Report..................................................................... 65 Figures and Tables........................................................................ 71 Published Version ........................................................................72 3. Diabetes Dyslipidaemia ......................................................... 73 Figures and Tables........................................................................ 86 Published Versions .......................................................................89 4. Glycation as an Atherogenic Modification of Lipoproteins, and the Contribution of Copper............................................................. 91 Figures and Tables.......................................................................109 5. How HDL Protects against Atherogenic Modification ................... 118 Figures and Tables.......................................................................128 Published Versions ..................................................................... 131

HDL functionality and lipoprotein quality in diabetes mellitus

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HDL functionality and lipoprotein quality in diabetes mellitus