Jonathan R. Scheerer
College of William & Mary
33 Papers
108 Citations
Jonathan R. Scheerer is an academic researcher from College of William & Mary. The author has contributed to research in topics: Cycloaddition & Aldol condensation. The author has an hindex of 13, co-authored 28 publications. Previous affiliations of Jonathan R. Scheerer include Harvard University & Johns Hopkins University.
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Papers
Deconstruction of iterative multidomain polyketide synthase function.
Jason M. Crawford,Paul M. Thomas,Jonathan R. Scheerer,Anna L. Vagstad,Neil L. Kelleher,Craig A. Townsend +5 more
TL;DR: It is found that dissection of PksA and its reconstitution from selected sets of domains allows the accumulation and characterization of advanced octaketide intermediates bound to the enzyme, permitting the reactions controlled by individual catalytic domains to be identified.
Interspecific and intraspecific hybrid Epichloë species symbiotic with the North American native grass Poa alsodes
Tatsiana Shymanovich,Nikki D. Charlton,Ashleigh M. Musso,Jonathan R. Scheerer,Nadja B. Cech,Stanley H. Faeth,Carolyn A Young +6 more
TL;DR: The endophyte presence and diversity in natural populations of Poa alsodes were evaluated along a latitudinal transect from the southern distribution range in North Carolina to New York, identifying two distinct Epichloë hybrid taxa that could easily be distinguished by polymerase chain reaction genotyping.
Efficient Entry to the [2.2.2]-Diazabicyclic Ring System via Diastereoselective Domino Reaction Sequence
TL;DR: A domino reaction sequence involving aldol condensation, alkene isomerization, and intramolecular hetero-Diels-Alder cycloaddition for the synthesis of [2.2. 2.2]-diazabicyclic structures is reported, generating molecular complexity and competent with both enolizable and nonenolizable aldehyde substrates.
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Synthesis of 2-pyridones by cycloreversion of [2.2.2]- bicycloalkene diketopiperazines.
TL;DR: Progress toward the synthesis of louisianin A and B, antiproliferative 2-pyridone natural products, is disclosed and a general strategy for the conversion of diazabicyclic alkene structures to 2- pyridones aromatic heterocyclic products is reported.
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Synthesis of Peramine, an Anti-insect Defensive Alkaloid Produced by Endophytic Fungi of Cool Season Grasses.
TL;DR: A seven-step synthesis of peramine, which required three chromatographic separations, is described, key to the synthesis is an enolate alkylation of a pyrrole-fused diketopiperazine to establish the pyrrolopyrazine core of peramines.
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