Jonathan P. Lambert
Temple University
34 Papers
59 Citations
Jonathan P. Lambert is an academic researcher from Temple University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 29 publications. Previous affiliations of Jonathan P. Lambert include University of Padua & Emory University.
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Papers
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition
Timothy S. Luongo,Jonathan P. Lambert,Ancai Yuan,Xue-Qian Zhang,Polina Gross,Jianliang Song,Santhanam Shanmughapriya,Erhe Gao,Mohit Jain,Steven R. Houser,Walter J. Koch,Joseph Y. Cheung,Muniswamy Madesh,John W. Elrod +13 more
TL;DR: The hypothesis that MCU may be dispensable for homeostatic cardiac function but required to modulate Ca(2+)-dependent metabolism during acute stress is supported.
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The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.
Timothy S. Luongo,Jonathan P. Lambert,Polina Gross,Mary Nwokedi,Alyssa A. Lombardi,Santhanam Shanmughapriya,April C. Carpenter,Devin W. Kolmetzky,Erhe Gao,Jop H. van Berlo,Emily J. Tsai,Jeffery D. Molkentin,Xiongwen Chen,Muniswamy Madesh,Steven R. Houser,John W. Elrod +15 more
TL;DR: It is shown that tamoxifen-induced deletion of Slc8b1 in adult mouse hearts causes sudden death, and overexpression of NCLX in the mouse heart by conditional transgenesis had the beneficial effect of augmenting mCa2+ clearance, preventing permeability transition and protecting against ischaemia-induced cardiomyocyte necrosis and heart failure.
296
A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number
Nawazish Naqvi,Ming Li,John W. Calvert,Thor Tejada,Jonathan P. Lambert,Jianxin Wu,Scott H. Kesteven,Sara R. Holman,Torahiro Matsuda,Joshua D. Lovelock,Wesley W. Howard,Siiri E. Iismaa,Siiri E. Iismaa,Andrea Y. Chan,Brian H. Crawford,Mary B. Wagner,David I. K. Martin,David J. Lefer,Robert M. Graham,Robert M. Graham,Ahsan Husain +20 more
TL;DR: It is shown that a thyroid hormone surge activates the IGF-1/IGF-1-R/Akt pathway on postnatal day 15 and initiates a brief but intense proliferative burst of predominantly binuclear cardiomyocytes, suggesting persistence of carduomyocyte proliferative capacity beyond the perinatal period.
296
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Pooja Jadiya,Devin W. Kolmetzky,Dhanendra Tomar,Antonio Di Meco,Alyssa A. Lombardi,Jonathan P. Lambert,Timothy S. Luongo,Marthe H.R. Ludtmann,Domenico Praticò,John W. Elrod +9 more
TL;DR: It is shown that mCa2+ overload contributes to AD progression by promoting superoxide generation, metabolic dysfunction and neuronal cell death, and is suggested as a potential therapeutic target in AD.
Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner
Bridgette F. Peake,Chad K. Nicholson,Jonathan P. Lambert,Rebecca L Hood,Hena Amin,Sana Amin,John W. Calvert +6 more
TL;DR: It is demonstrated for the first time that exogenous administration of Na2S attenuates myocardial ischemia-reperfusion injury in db/db mice, suggesting the potential therapeutic effects of H2S in treating a heart attack in the setting of type 2 diabetes.
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